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Hepatitis C infection in Egypt: prevalence, impact and management strategies

Authors Gomaa A, Allam N, Elsharkawy A, El Kassas M, Waked I

Received 26 January 2017

Accepted for publication 12 April 2017

Published 15 May 2017 Volume 2017:9 Pages 17—25

DOI https://doi.org/10.2147/HMER.S113681

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Gerry Lake-Bakaar


Video abstract presented by Naglaa Allam.

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Asmaa Gomaa,1 Naglaa Allam,1 Aisha Elsharkway,2 Mohamed El Kassas,3 Imam Waked1

1Hepatology Department, National Liver Institute, Shebeen EL Kom, 2Endemic Medicine Department, Faculty of Medicine, Cairo University, 3Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt

Abstract: Hepatitis C virus (HCV) infection is a major public health burden in Egypt, where it bears the highest prevalence rate in the world. Estimates for prevalence are based upon data reported from the 2008 and 2015 Egypt Demographic Health Surveys. In this review, we demonstrate the prevalence results of both surveys and analyze the difference in the results. The overall HCV prevalence is estimated to be declining. However, the clinical impact of chronic HCV infection is expected to grow considerably. A mathematical model shows that by increasing the rate of treatment, the expected number of patients will decline significantly in 2030. The current and expected future burden of chronic HCV infection to the Egyptian economy, including direct and indirect costs due to disability and loss of lives, has been estimated and discussed in this review. The economic burden will continue to grow, but a model shows that the introduction of highly effective therapies will result in a significant reduction in the cumulative total economic burden of HCV by 2030. In recognition of the HCV tremendous health and economic burden, the Egyptian government established the National Committee for Control of Viral Hepatitis to implement an integrated nationwide strategy to provide patient care and ensure global treatment access. This review illustrates the epidemiological and disease burden aspects of HCV in Egypt in addition to introducing the national plan and program for managing HCV, which has been successful so far in treating a large number of patients, with the aim of achieving disease control and eventual elimination in Egypt.

Keywords: hepatitis C in Egypt, prevalence, HCV burden, treatment strategy
Corrigendum for this paper has been published

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