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Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

Authors Ahn KT, Park KI, Kim MJ, Oh JK, Han JH, Kwon HJ, Jin SA, Kim JH, Park JH, Lee JH, Choi SW, Seong IW, Jeong JO

Received 25 November 2015

Accepted for publication 23 January 2016

Published 11 April 2016 Volume 2016:11 Pages 415—422

DOI https://doi.org/10.2147/CIA.S101302

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Supriya Swarnkar

Peer reviewer comments 3

Editor who approved publication: Dr Richard Walker

Kye Taek Ahn, Kwang-In Park, Mi Joo Kim, Jin Kyung Oh, Ji Hye Han, Hee Jin Kwon, Seon-Ah Jin, Jun-Hyung Kim, Jae-Hyeong Park, Jae-Hwan Lee, Si Wan Choi, In-Whan Seong, Jin-Ok Jeong

Department of Internal Medicine, Division of Cardiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea

Objectives: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes.
Methods: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension.
Results: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=-0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R2=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=-0.632, 95% CI for height -0.929 to -0.335, P-value =0.009, respectively).
Conclusion: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75.

Keywords: hypertension, augmentation index, height, sex

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