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Golimumab for the treatment of ulcerative colitis

Authors Löwenberg M, de Boer N, Hoentjen F

Received 10 January 2014

Accepted for publication 3 February 2014

Published 12 March 2014 Volume 2014:7 Pages 53—59


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Mark Löwenberg,1 Nanne KH de Boer,2 Frank Hoentjen3

1Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, the Netherlands; 2Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, the Netherlands; 3Inflammatory Bowel Disease Center, Radboud University Medical Center, Nijmegen, the Netherlands

Abstract: The introduction of therapeutic antibodies against tumor necrosis factor (TNF) had a major impact on the treatment of ulcerative colitis (UC). Infliximab and adalimumab are powerful agents that are used for remission induction and maintenance therapy in UC and have an acceptable safety profile. However, a proportion of UC patients for whom therapy with anti-TNF agents is indicated fail or become intolerant to treatment with infliximab or adalimumab. Hence, there remains an unmet need for novel anti-TNF agents. Golimumab (Simponi®), a human anti-TNF antibody that is administered by monthly subcutaneous injections, is the most recently introduced TNF blocker for the treatment of UC. Here, we will discuss recent literature on clinical efficacy and safety of golimumab induction and maintenance treatment in patients with UC. Furthermore, we will discuss the positioning of golimumab for UC in current treatment algorithms.

Keywords: ulcerative colitis, UC, antitumor necrosis factor, TNF, antibodies, golimumab

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