Back to Journals » Clinical Ophthalmology » Volume 7

Glistenings in hydrophobic acrylic intraocular lenses do affect visual function

Authors Beiko GHH, Grzybowski A

Received 4 August 2013

Accepted for publication 5 August 2013

Published 27 November 2013 Volume 2013:7 Pages 2271—2274

DOI https://doi.org/10.2147/OPTH.S52489

Checked for plagiarism Yes

George HH Beiko,1,2 Andrzej Grzybowski3,4

1Department of Surgery, McMaster University, Hamilton, ON, Canada; 2Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; 3Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland, 4Department of Ophthalmology, Poznan City Hospital, Poznan, Poland

We recently read the paper "Evaluation of in vitro glistening formation in hydrophobic acrylic intraocular lenses" by Thomes and Callaghan.1 The paper is extremely interesting in that the authors, employees of Alcon Research Ltd (Forth Worth, TX, USA), report not only that Alcon lenses have glistenings, but also that "continuous improvements on glistening formation"1 have been made by Alcon over the years from 2003 to 2012. We congratulate the authors and Alcon on their efforts, and on making this admission.

The paper raises a number of concerns and questions. Firstly, the statement in the introduction, "Glistenings are typically observed within a few months of surgery and plateau approximately 1 year after surgical implantation of the [intraocular lens] IOL"1 is not referenced. The reported literature is in contradiction to this statement, in that the glistenings formation, as well as the severity of glistenings, has been reported to increase with longer follow-up times.2–8 Very few studies that evaluate the progression beyond one year find glistening formation to be stable.9–10 In addition, this statement is contradicted by the authors themselves in the introduction section of this paper where they state that a study by Colin et al4 found that 73.8% of the IOLs had glistenings when follow-up was less than 2 years, and 94.2% of the IOLs had glistenings when the follow-up was longer than 2 years. Even after10 years of follow-up, no plateau was seen.2

View original paper by Thomes and Callaghan.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers

Nagelschmitz J, Blunck M, Kraetzschmar J, Ludwig M, Wensing G, Hohlfeld T

Clinical Pharmacology: Advances and Applications 2014, 6:51-59

Published Date: 19 March 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010