Back to Archived Journals » Journal of Receptor, Ligand and Channel Research » Volume 2

GIRK2 and neuronal pattern of generation and settling in homozygous weaver mice

Authors Marti-Clua J, Santa-Cruz MC, Bayer SA, Hervás JP

Published 12 October 2009 Volume 2009:2 Pages 29—44


Review by Single anonymous peer review

Peer reviewer comments 2

Joaquín Martí1,3, María C Santa-Cruz1, Shirley A Bayer2, José P Hervás1,3

1Unidad de Citología e Histología, Facultad de Biociencias, Universitat Autònoma de Barcelona, Campus Bellaterra, Spain; 2Laboratory of Developmental Neurobiology. Indianapolis, Indiana, USA; 3Both authors contributed equally to this work

Abstract: G-protein-activated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Several GIRK channel subunits have been found in the central nervous system. The weaver mutation has been identified as a single base-pair substitution in the gene encoding for a GIRK channel subunit, GIRK2. The cerebellum and the mesencephalon are predominately affected in the homozygous weaver mouse (wv/wv). In this article, we review our main findings about the patterns of cell generation, survival, and settling of two neuronal types in the wv/wv: Purkinje cells in the cerebellar cortex and dopaminergic neurons in the ventral midbrain. Moreover, we examine if the time of neuron origin determines the degree of cell vulnerability to the lethal action of mutated GIRK2. The possible involvement of other GIRK channel subunits is also considered within the context of earlier and more recent studies in the field.

Keywords: Purkinje neurons, dopaminergic neurons, GIRK2, weaver mouse, neurogenetic timetable

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]