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Genetic polymorphisms in IL-7 and IL-7R are correlated with lung cancer risk in the Chinese Han population

Authors Zhang C, Su P, Chen W, Li Q, Dai R, Cheng YJ, Yang J

Received 24 January 2019

Accepted for publication 30 April 2019

Published 11 June 2019 Volume 2019:11 Pages 5393—5401

DOI https://doi.org/10.2147/CMAR.S202839

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Rituraj Purohit


Chan Zhang,1 Pincan Su,2 Wanlu Chen,1 Qi Li,1 Run Dai,1 YuJing Cheng,1 Jiangcun Yang3

1Department of Blood Transfusion, The First People’s Hospital of Yunnan Province, Kunming, Yunnan 650032, People’s Republic of China; 2Laboratory of Blood Transfusion, Yunnan Kunming Blood Center, Kunming, Yunnan 650106, People’s Republic of China; 3Department of Transfusion Medicine, Shanxi Provincial People’s Hospital, Xi’an, Shaanxi 710068, People’s Republic of China

Purpose: IL-7/IL-7R axis participates in the initiation and progression of lung cancer (LC). This study aimed to explore the potential influence of IL-7/IL-7R polymorphisms on LC risk.
Patients and methods: In total, 1,010 participants (507 LC patients and 503 healthy controls) were enrolled. Five single-nucleotide polymorphisms (SNPs) in IL-7R and one SNP in IL-7 were genotyped in included samples with Agena MassARRAY system. OR and 95% CIs were computed by logistic regression analysis after adjusting for age and gender. Stratified analyses with demographic and clinical characteristics were also performed. Finally, linkage disequilibrium (LD) analysis was conducted with the PLINK version 1.07 software.
Results: IL-7R rs10053847 variant was related to a decreased LC risk under the allele gene (OR =0.78, P=0.043) and additive model (OR =0.77, P=0.042). The results of stratified analysis indicated that this SNP was associated with a lower LC risk among nonsmokers (AA/GG: OR =0.09, P=0.033; AA/AG+GG: OR =0.10 P=0.037) or nondrinkers (AA/GG: OR =0.07, P=0.047; AA/AG+GG: OR =0.18 P=0.049). Moreover, carriers of IL-7R rs10213865-C allele had an increased lung adenocarcinoma risk (CA/AA: OR =1.60, P=0.011; CC+CA/AA: OR =1.62, P=0.007; CA/CA/AA: OR =1.50, P=0.007). Additionally, AGAA haplotype (rs10213865, rs969129, rs118137916 and rs10053847) increased LC risk (OR =1.30, P=0.041).
Conclusion: IL-7R rs10053847 was correlated with a decreased LC risk, while IL-7R rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation.

Keywords: lung cancer, IL-7R, IL-7, polymorphisms, cancer susceptibility, case-control study
 

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