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Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Authors Tarnowski M, SĹ‚uczanowska-GĹ‚abowska S, Pawlik A, Mazurek-Mochol M, Dembowska E

Received 3 December 2016

Accepted for publication 18 February 2017

Published 6 April 2017 Volume 2017:13 Pages 439—446

DOI https://doi.org/10.2147/TCRM.S129327

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

Maciej Tarnowski,1 Sylwia Słuczanowska-Głabowska,1 Andrzej Pawlik,1 Małgorzata Mazurek-Mochol,2 Elżbieta Dembowska2

1Department of Physiology, 2Department of Periodontology, Pomeranian Medical University, Szczecin, Poland

Abstract: Posttransplant diabetes mellitus (PTDM) is one of the major metabolic complications after transplantation of solid organs including the kidney. This type of diabetes mellitus affects allograft survival, cardiovascular complications and overall patient survival. The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. Currently, predisposing genetic factors have been considered important in PTDM development. The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ionic channels, glucose transporters, cytochrome P450 enzymes and other enzymes metabolizing drugs, drug transporters. Unfortunately, the results of studies are inconclusive and differ between populations. There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development.

Keywords: diabetes mellitus, kidney, transplantation, gene polymorphism, SNP

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