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Functionalization of carboxylated multiwall nanotubes with imidazole derivatives and their toxicity investigations

Authors Azizian J, Tahermansouri H, Biazar E, Heidari S, Khoei DC

Published 4 November 2010 Volume 2010:5 Pages 907—914

DOI https://doi.org/10.2147/IJN.S13629

Review by Single-blind

Peer reviewer comments 4


Javad Azizian1, Hasan Tahermansouri1, Esmaeil Biazar2, Saeed Heidari3, Davood Chobfrosh Khoei1
1Department of Chemistry, Science and Research branch, Islamic Azad University, Ponak, Tehran, Iran; 2Young researchers club – Islamic Azad University, Tonekabon Branch, Iran; 3Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshty University of Medical Sciences,Tehran, Iran

Abstract: Imidazoles and their derivatives are compounds with chemotherapeutic applications. In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWNT–COOH) by 1,2-phenylendiamine. Multiwalled nanotube (MWNT)–benzimidazole was obtained by an MWNT–amide reaction with POCl3 after 72 hours, which was confirmed by Fourier transform infrared, scanning electron microscopy, thermal gravimetric analysis, and elemental analysis. These functionalizations were chosen due to -NH2 and NHCO active sites in MWNT–amide for future application. Toxicity assays with fibroblast cells and MTT test for measurement of viable cell numbers were also performed. Cellular results did not show any toxicity change in modified samples from that of the reference samples.

Keywords: functionalization, 1,2-phenylendiamine, carboxylated multiwall nanotubes, toxicity

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