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Fresh hypothermically stored amniotic allograft in the treatment of chronic nonhealing ulcers: a prospective case series

Authors Sabo M, Moore S, Yaakov R, Doner B, Patel K, Serena TE

Received 5 October 2017

Accepted for publication 9 January 2018

Published 13 April 2018 Volume 2018:5 Pages 1—4

DOI https://doi.org/10.2147/CWCMR.S153317

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Professor Marco Romanelli


Matthew Sabo,1 Sarah Moore,2 Raphael Yaakov,2 Bryan Doner,3 Keyur Patel,3 Thomas E Serena2

1The Foot and Ankle Wellness Center of Western Pennsylvania, Ford City, PA, USA; 2SerenaGroup®, Hingham, MA, USA; 3The Snyder Institute, ACMH Hospital, Kittanning, PA, USA

Introduction: Amniotic membranes have been used for a variety of surgical applications since the 1900s. Recent developments in the field of chronic wound care have accelerated and expanded their use. To date, there are over 70 amniotic products available, including dehydrated human amnion/chorion and cryopreserved human amnion. The integrity of these grafts, however, may be compromised during processing. Fresh hypothermically stored amniotic allograft (HSAM) may improve healing rates by preserving growth factors and living cells, including stem cells, as well as retaining the membrane’s native structure.
Methods: Healing outcomes were evaluated in patients receiving HSAM for the treatment of chronic nonhealing ulcers. Relevant medical history was captured in addition to data on wound characteristics and measurements. Two venous leg ulcers and one postsurgical wound were treated with HSAM.
Findings: A significant reduction in wound size was observed for patients treated with HSAM. Overall, HSAM demonstrated a wound size reduction of 93.94% in 42 days. These results provide evidence that HSAM may reduce the long-term costs associated with the care of chronic ulcers by increasing the healing rate and lowering the risk of infection and complications.

Keywords: chronic wounds, regenerative medicine, wound care, amnion, hypothermically stored amniotic membrane

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