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Formation of a vesicovaginal fistula in a pig model

Authors Lindberg J, Rickardsson E, Andersen M, Lund L

Received 1 August 2014

Accepted for publication 1 October 2014

Published 14 August 2015 Volume 2015:7 Pages 113—116

DOI https://doi.org/10.2147/RRU.S72119

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Jan Colli


Jennifer Lindberg,1 Emilie Rickardsson,1 Margrethe Andersen,2 Lars Lund1,2

1Clinical Institute, University of Southern Denmark, Odense, 2Department of Urology, Odense University Hospital, Odense C, Denmark

Objective: To establish an animal model of a vesicovaginal fistula that can later be used in the development of new treatment modalities.
Materials and methods: Six female pigs of Landrace/Yorkshire breed were used. Vesicotomy was performed through open surgery. An standardized incision between the bladder and the vagina was made, and the mucosa between them was sutured together with absorbable sutures. A durometer ureteral stent was introduced into the fistula, secured with sutures to the bladder wall, allowing for the formation of a persistent fistula tract. Six weeks postoperatively cysto-scopy was performed to examine the fistula in vivo. Thereafter, the pigs were euthanized with intravenous pentobarbital.
Results: Two out of four (50%) pigs developed persistent fistulas. No per- or postoperative complications occurred.
Conclusion: This study indicates that this pig model of vesicovaginal fistula can be an effective and cheap way to create a fistula between the bladder and vagina.

Keywords: vesicovaginal fistula, urinary fistula, animal model

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