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First experience with BAK-free travoprost 0.004% in topical glaucoma medication

Authors Gado, Macky T

Published 13 December 2011 Volume 2012:6 Pages 1—4

DOI https://doi.org/10.2147/OPTH.S24983

Review by Single-blind

Peer reviewer comments 3


Ahmed Salah Gado, Tamer Ahmed Macky
Department of Ophthalmology, Cairo University, Cairo, Egypt

Objectives: Benzalkonium chloride (BAK)-free travoprost 0.004% (Travatan Z®, Alcon Laboratories, Inc, Fort Worth, TX) is a new formulation that was developed with the aim of creating a formulation of travoprost that would maintain the intraocular pressure (IOP)-lowering efficacy and have an improved overall safety profile, particularly improved ocular surface tolerability.
Methods: Thirty newly diagnosed primary open-angle glaucoma (POAG) patients were treated with BAK-free travoprost 0.004%. IOP readings were recorded at baseline before initiating treatment, at 4–6 weeks, and after 12 weeks of starting treatment. In addition, patient demographics, subjective symptoms (ie, burning, foreign-body sensation, itching, and stinging), and objective clinical signs such as conjunctival hyperemia were collected. Subjective symptoms were evaluated using a four-point scale ranging from “no symptoms,” “mild symptoms,” “moderate symptoms” to “severe symptoms.” As for clinical signs, severity of conjunctival hyperemia was evaluated. All other adverse events were collected.
Results: BAK-free travoprost 0.004% provided an IOP decrease in all patients, with an overall mean of 28.3 ± 2.1 mmHg at baseline to a mean of 18.7 ± 1.6 mmHg at 4–6 weeks, and a mean of 18.4 ± 1.4 mmHg after 12 weeks. Both subjective symptoms and objective clinical signs were very few after treatment.
Conclusion: The results demonstrate that BAK-free travoprost 0.004% is an effective, well tolerated, and safe medication in POAG patients.

Keywords: primary open-angle glaucoma, POAG, benzalkonium chloride, Travatan

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