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Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Authors Sachot N, Roguska A, Planell JA, Lewandowska M, Engel E, Castaño O

Received 28 February 2017

Accepted for publication 10 May 2017

Published 11 July 2017 Volume 2017:12 Pages 4901—4919

DOI https://doi.org/10.2147/IJN.S135806

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Alexander Kharlamov

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Nadège Sachot,1,2 Agata Roguska,3 Josep Anton Planell,1,2 Malgorzata Lewandowska,3 Elisabeth Engel,1,2,4 Oscar Castaño1,2,5,6

1Biomaterials for Regenerative Therapies, Institute for Bioengineering of Catalonia (IBEC), Barcelona, 2CIBER en Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Zaragoza, Spain; 3Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland; 4Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), 5Department of Materials Science and Physical Chemistry, Universitat de Barcelona (UB), 6Department of Engineerings: Electronics, Universitat de Barcelona, Barcelona, Spain

Abstract: The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior. Here, blended polylactic acid (PLA) calcium phosphate ORMOGLASS (organically modified glass) nanofibrous mats have been incubated up to 4 weeks in physiological simulated conditions, and their morphological, topographical, and chemical changes have been investigated. The results showed that a significant loss of inorganic phase occurred at the beginning of the immersion and the ORMOGLASS maintained a stable composition afterward throughout the degradation period. As a whole, the nanostructured scaffolds underwent fast and heterogeneous degradation. This study reveals that an angiogenic calcium-rich environment can be achieved through fast-degrading ORMOGLASS/PLA blended fibers, which seems to be an excellent alternative for guided bone regeneration.

Keywords: electrospinning, fast degradation, ORMOGLASSES, angiogenesis, nanofibers, calcium release
 

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