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Factors Influencing Medication Nonadherence to Pulmonary Tuberculosis Treatment in Tibet, China: A Qualitative Study from the Patient Perspective

Authors Zhang J, Yang Y, Qiao X, Wang L, Bai J, Yangchen T, Chodron P

Received 12 March 2020

Accepted for publication 19 June 2020

Published 10 July 2020 Volume 2020:14 Pages 1149—1158

DOI https://doi.org/10.2147/PPA.S252448

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Naifeng Liu


Jinjing Zhang,1,* Yunyun Yang,2,* Xue Qiao,1 Liwen Wang,1 Jinyu Bai,1 Tsring Yangchen,1 Pema Chodron1

1School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, People’s Republic of China; 2Department of Pulmonary, The Third People’s Hospital of Tibet Autonomous Region, Lhasa, Tibet, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jinjing Zhang
School of Medicine, Xizang Minzu University, #6 Wenhui East Road, Xianyang 712082, Shaanxi, People’s Republic of China
Tel +86 186 9100 8710
Fax +86 029 3375 5433
Email jinjingzhang@xzmu.edu.cn

Purpose: Medication nonadherence is one of the most significant obstacles to tuberculosis (TB) control worldwide. Identification of the factors associated with medication nonadherence is important. However, few related studies have been carried out in Tibet. This study aimed to explore factors influencing medication nonadherence to pulmonary TB (PTB) treatment in Tibet, China, from the patient perspective.
Patients and Methods: In this qualitative study, seventeen PTB patients in Tibet were recruited by purposive and maximum variation sampling methods. In-depth semistructured interviews were conducted to collect data on factors influencing medication nonadherence, and Colaizzi’s seven-step method was used to analyze the data.
Results: The medication nonadherence of PTB patients in Tibet was influenced by one or a combination of the following four factors. First, patient-related factors included a lack of knowledge of PTB treatment, poor self-management capability, poor self-regulation capability and misperception of health condition. Second, a medication-related factor was medication side effects. Third, health service-related factors included the poor treatment skills of doctors in primary hospitals and a lack of directly observed treatment (DOT). Last, sociocultural factors included the effect of traditional Tibetan medicine, lack of family member support and discrimination.
Conclusion: Multiple interplaying factors influenced medication nonadherence during PTB treatment in Tibet, and the main influencing factors were a lack of knowledge about PTB treatment, poor self-management capability, and the effect of traditional Tibetan medicine. TB health workers in Tibet should provide permanently viewable PTB treatment knowledge materials to PTB patients when oral health education is conducted, find feasible alternative strategies to DOT and establish links to traditional Tibetan medicine hospitals.

Keywords: pulmonary tuberculosis, medication compliance, in-depth interview, influencing factor

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