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Factors associated with human papillomavirus infection – findings from a cervical cancer screening program for female employees in Beijing

Authors Yang H, Zhong Y, Lv W, Yu H

Received 20 March 2019

Accepted for publication 6 August 2019

Published 28 August 2019 Volume 2019:11 Pages 8033—8041

DOI https://doi.org/10.2147/CMAR.S209322

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Dr Beicheng Sun


Hui-xia Yang, Yu Zhong, Wei-hua Lv, Hong Yu

Labor Model Health Management Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, People’s Republic of China

Correspondence: Hong Yu
Labor Model Health Management Center, Beijing Rehabilitation Hospital, Capital Medical University, Xixiazhuang, Badachu, Shijingshan District, Beijing 100144, People’s Republic of China
Tel +86 105 698 1131
Fax +86 105 698 1131
Email y_hong@aliyun.com

Background: In 2018, the Beijing Federation of Trade Unions organized a cervical cancer screening program for female employees for the first time. This study aimed to investigate the screening results of this program and determine the factors associated with human papillomavirus (HPV) infection.
Methods: A total of 8297 female employees participating in the screening program between January 1, 2018, and December 31, 2018, were enrolled in this study. The methods for screening cervical cancer included ThinPrep cytology test (TCT) and HPV genotyping test. Single-factor analysis and multiple binary logistic regression analysis were used to identify the factors associated with HPV infection.
Results: Of the 8297 women (median age: 43.00 years), TCT was found to be abnormal in 116 patients (1.40%) and 1169 (14.09%) were positive for HPV genotyping test. Notably, HPV-52 was the most prevalent subtype (3.05%), followed by HPV-16 (2.82%), HPV-58 (2.01%), HPV-51 (1.58%) and HPV-56 (1.49%). Multivariate logistic regression analysis revealed that taxi drivers (OR =1.98; 95% CI =1.31–2.99) and single women with a history of sexual activity (OR =2.32; 95% CI =1.41–3.82) were significantly associated with an increased risk of HPV infection (P<0.05), whereas medical workers (OR =0.67; 95% CI =0.51–0.88) and factory workers (OR =0.36; 95% CI =0.17–0.77) were protective factors for HPV infection (P<0.05).
Conclusion: HPV-52, HPV-16 and HPV-58 are the most common types of high-risk HPV among female employees in Beijing. Being taxi drivers and single women with a history of sexual activity are significantly associated with the risk of HPV infection.

Keywords: cervical cancer screening, HPV types, cervical cytology, occupation, Beijing
 

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