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External Validation Of The Surgical Mortality Probability Model (S-MPM) In Patients Undergoing Non-Cardiac Surgery

Authors Kazimierczak S, Rybicka A, Strauss J, Schram M, Kazimierczak A, Grochans E

Received 17 April 2019

Accepted for publication 29 August 2019

Published 4 October 2019 Volume 2019:15 Pages 1173—1182


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

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Sebastian Kazimierczak,1 Anita Rybicka,2 Jochen Strauss,1 Malgorzata Schram,3 Arkadiusz Kazimierczak,4 Elżbieta Grochans2

1Anesthesiology, Perioperative Care and Pain Therapy Department, HELIOS Hospital, Berlin-Buch, Germany; 2Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University, Szczecin, Poland; 3Department of Anesthesiology and Intensive Care Medicine, Evangelisch-Freikirchliches Krankenhaus Bernau, Bernau Bei Berlin, Germany; 4Vascular Surgery Department of Pomeranian Medical University, Szczecin, Poland

Correspondence: Anita Rybicka
Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University, ul. Żołnierska 48, Szczecin 71-210, Poland
Tel +48 91 48 00 910
Fax +48 91 48 00 905
Email [email protected]

Background: Preoperative risk assessment is a key issue in the process of patient preparation for surgery and the control of quality improvement in health care and certification programs. Hence, there is a need for a prognostic tool, whose usefulness can be assessed only after validation in the center other than the home one. The aim of the study was to validate the Surgical Mortality Probability Model (S-MPM) for detecting deaths and complications in patients undergoing non-cardiac surgery and to assess its suitability for various surgical disciplines.
Methods: This retrospective study involved 38,555 adult patients undergoing non-cardiac surgery in a single center in 2012–2015. The observation period concerned in-hospital mortality.
Results: In-hospital mortality for the total population was 0.89%. Mortality in the S-MPM I class amounted to 0.26%, S-MPM II 2.51%, and in the S-MPM III class 22.14%. This result was in line with those obtained by the authors. The discriminatory power for in-hospital mortality was good (area under curve (AUC) = 0.852, 95% CI: 0.834–0.869, p = 0.0000). The scale was the most accurate in general surgery (AUC = 0.89, 95% CI: 0.858–0.922) and trauma (AUC = 0.89; 95% CI: 0.87–0.915). In the logistic regression analysis, the scale showed a perfect fit/goodness of fit in the cross-validation method (v-fold cross-validation): Hosmer–Lemeshow (HL) = 7.945; p = 0.159. This result was confirmed by the traditional derivation and validation data set method (1:3; 9712 vs 22.748 cases): HL test = 3.073 (p = 0.546) in the teaching derivation data set and 10.77 (p = 0.029) in the test sample (validation data set).
Conclusion: The S-MPM scale by Glance et al has proven to be a useful tool to assess the risk of in-hospital death and can be taken into account when considering treatment indications, patient information, planning post-operative care, and quality control.

Keywords: S-MPM, early mortality, in-hospital mortality, ASA, RCRI


The effectiveness of quality improvement programs in healthcare and certification systems must be monitored regularly. This requires continuous monitoring of the results of surgical treatment and is the basis for pay-for-performance financing.1 In order to compare the results of treatment (mortality, complications) between centers, we need to know the exact anticipated risk that arises from the patient’s burden of accompanying diseases.

Tools for evaluating this risk must be accurate, easy to use, and be able to be used without a computer.2,3 The scale of risk is considered to be effective if it has good discriminatory power (the ability to properly qualify the patient to one of the risk groups), good calibration (matching the expected results to those observed), and is independent of the user experience.

It is important that prior to the implementation of the practice the given scale should be validated in the external environment, because the prognostic properties of any scale are best in the population on which the scale was designed (derivation group) and do not need to be confirmed when these scales are applied to a new population or in another resort.2

The current European Society of Cardiology/European Society of Anesthesiology (ESC/ESA) 2014 guidelines recommend two risk scales: the Surgery Risk Calculator of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) and the Revised Cardiac Risk Index (RCRI).4 On the one hand, we have an exact, but complicated (35 variables required for calculation) ACS-NSQIP, on the other-RCRI-ineffective in predicting general mortality, because only about 45% of the deaths are caused by cardiac causes.5

The authors of the Surgical Mortality Probability Model (S-MPM) attempted to realign the risk assessment before each operation in a situation of limited time, financial and personnel resources. It contains in a simplified form the two most important risk components―patient risk and operational risk. Glance et al emphasizes that the purpose of his work was to create a simplified alternative to the NSQIP calculator, not to replace it.6 The population, on the basis of which the S-MPM scale was created, constituted 298,772 patients operated on in more than 200 hospitals participating in the NSQIP program in the USA. According to the information available to the author, the S-MPM scale has not yet been validated in the external center.


The aim of the study was to validate the S-MPM scale in detecting deaths and complications in patients undergoing non-cardiac surgery and its suitability for various surgical disciplines.

Materials And Methods

It is a retrospective analysis of data routinely registered in hospital database with compliance of EU GDPR (eng) – European Union General Data Protection Regulation; therefore, it does not need additional approval of Bioethical Comity.

The data come from a single high reference center with an average annual plan of 30,000 operations undergoing non-cardiac surgery over a period of 3 years. There were no any exclusion criteria. One hundred and thirty variables for each patient were collected by clinicians using the hospital information system, including interview data (concomitant diseases, risk factors, physical performance, functional status) and basic research. The observed event was in-hospital mortality.

In the case of ophthalmology, pediatric surgery, and urogynecology, no hospital-related deaths were recorded.

For validation, we have used original S-MPM developed by Glance et al, which is a 9-point 30-day mortality risk index. It includes three risk factors: American Society of Anesthesiologists (ASA) physical status (PS), surgery risk class and emergency status. Patients with ASA PSI, II, III, IV, or V were assigned either 0, 2, 4, 5, or 6 points, respectively. Intermediate or high-risk procedures were assigned 1 or 2 points, respectively. Emergency procedures were assigned 1 point. Patients with risk scores less than 5 had a predicted risk of mortality less than 0.5%, whereas patients with a risk score of 5 to 6 had a risk of mortality between 1.5% and 4.0%. Patients with a risk score greater than 6 had a risk of mortality more than 10%.

All our data needed to complete the S-MPM model were the subsequently subject to statistical analysis.

Statistical Analysis

The data were analyzed using the Statistica 12 program. To determine the impact of individual components of the S-MPM scale on in-hospital mortality, a stepwise regression model (unadjusted and adjusted odds ratio [OR]) was used to integrate the data into the model using the reference coding method. The discriminatory scale of the scale was evaluated using the AUC analysis, C-statistic for the entire study group and for individual treatment disciplines. The validation was performed by dividing the test group into a computational and validation (derivation and validation data set) using the cross-validation method (v-fold cross-validation) and traditionally (1:3), the Hosmer–Lemeshow test (goodness of fit) and graphically. In addition, the expected mortality was compared based on the original work of Glance et al with observed mortality.


The data cover 38,559 patients over 17 years of age (Table 1). The data refer to eleven treatment disciplines (Table 2). A total of 6080 patients were excluded from the study due to missing data necessary to calculate the S-MPM score.

Table 1 Numbers In Risk Groups (0–9) And Risk Classes (I–III) S-MPM

Table 2 Distribution Of Cases In Individual Treatment Disciplines

The group included 49.5% women and 50.5% men. The average age of patients was 55 years with an inter-quartile range (IR) between 33 and 69 years, with the average age of women being 49, men being 50 years old. As high as 17.5% of the cases were declared as urgent. Almost half of the treatments were classified as low-risk operations, 30% of medium risk and 20% of high risk. In-hospital mortality in the total population was 0.89%. The average time of hospitalization among people who died was 26 days (95% CI: 23.7–28.3/min 1 day to max 101 days/median: 21 days).

Demographic data are presented in Tables 3 and 4.

Table 3 Demographic Data And Risk Factors Of The Studied Population

Table 4 Demographic Data And Risk Factors Of The Studied Population

In the ASA I class, in-hospital mortality rate was 0.04%, in the ASA II class 0.25%, in the ASA III class 2.01%, in the ASA IV class 13.74, and in the ASA V class 40.9%. In-hospital mortality in class I S-MPM was 0.26%, in class II S-MPM 2.51%, and in class III S-MPM 22.14%. It was therefore in the ranges proposed in the original work Glance et al.6

The resting dyspnea was 0.4% of the patients in class I S-MPM, 2.5% in class II S-MPM, and 16.2% in class S-MPM III. Good physical capacity, understood as the ability to enter the second floor without interruption, had 30% of the patients in class I, 25% in class II, and 8.5% of the patients in class III S-MPM. The patient clinical complexity level (PCCL) was on average 1.05 in class I, 2.49 in class II, and 3.52 in class III S-MPM.

Using independent variables needed to build the S-MPM model, we made our own logistic regression analysis. The obtained regression coefficients slightly differed from those estimated by Glance et al (our own log relative for ASA 2 = 1.65 vs 2.009 in Glance et al, our own logistic co-operation for urgent surgery = 1.1 vs 0.934 in Glance et al). Only the operational risk ratios differed significantly from those proposed by the authors of S-MPM (our own logistical co-operation for medium-risk operations = 0.79 vs 1.25 in Glance et al and for high-risk operations = 0.91 vs 2.06 in Glance et al) (Table 5).

Table 5 Logistic Regression Results For S-MPM Scale Components

The ASA V class was excluded from further analysis. This is due to the fact that the presence of this class caused a mathematical error in the estimation procedure due to the incorrect distribution of the variable (small group size). The validation was performed using the cross-validation (v-fold cross-validation) method. The scale has shown a good fit/goodness of fit/- H–L (Hosmer–Lemeshow) = 7.945; p = 0.159 (Table 6).

Table 6 Deaths Observed Vs Predicted In The H–L Test

This result was confirmed in the second method, in which the test group was divided into a teaching and a test sample 1:3 (9712 vs 22,748 cases). The H–L test was 3.073 (p = 0.546) in the training sample and 10.77 (p = 0.029) in the test sample. This result is even better than that obtained by the authors of the S-MPM (teaching test: H–L = 5.53, p = 0.35 and test: H–L = 13.0, p = 0.023).

The Statistica program automatically divides the test sample into six subgroups with a similar level of risk of an event (in this case death). For each of the subgroups, the expected risk is calculated separately. The next step is comparing it with the observed risk. It should be noted that in the case of very large populations, even small differences can reach the level of statistical significance and erroneously suggest a poor fit of the model (Table 7).7

Table 7 Deaths Observed Vs Predicted In S-MPM Risk Groups

The S-MPM scale showed a good discriminatory power of in-hospital mortality in ROC (receiver operating characteristics) analysis in the whole study group. The AUC was 0.852 (95% CI: 0.834–0.869); p = 0.00001 (Figure 1).

Figure 1 AUC plot of mortality discrimination for the S-MPM scale.

The analysis of the usefulness of the S-MPM scale in individual surgical disciplines showed the best discriminatory force (ROC) in general and traumatic surgery (Table 8).

Table 8 AUC Of S-MPM Scale In Individual Surgical Disciplines

Due to the highest number of treatments for vascular, general and traumatic surgery as well as significant differences in mortality and logistics of hospital work organization, the results are presented separately (Figure 2).

Figure 2 Mortality in S-MPM (I–III) classes for vascular, general, and traumatic surgery.


S-MPM And Other Scores

Our results confirm the S-MPM scale is the most accurate in general surgery and trauma (with high AUC=0.852) and showed a perfect fit/goodness in H–L test. Moreover, simplicity of S=MPM score is beneficial compared to other available and recommended tools.

Recommended, among others by ESA Guidelines NSQIP Surgical Risk Calculator was created at a huge cost, based on a group of over 1,400,000 patients and almost 400 hospitals included in the ACS-NSQIP.4 It has an excellent discriminatory power in predicting the risk of death within 30 days of surgery (AUC = 0.944) and the risk of typical surgical complications (AUC = 0.816).8 However, it should be remembered that the additional cost of running an NSQIP system for a participating hospital is estimated at $ 100,000 per year.1

Despite the costs of participation in the program, in net settlement, it brings measurable savings. Apart from the economic aspect, participation in the NSQIP program, according to the authors, means a significant reduction in complications and mortality (250–500 complications annually and 12–36 deaths less) (Source:

On the other hand, only 3% of the total number of hospitals in the US decides to participate in this program. The reason is the time and costs of collecting data necessary to calculate the risk using the NSQIP calculator.1,6

In a comprehensive meta-analysis from 2013, Moonesinghe et al analyzed 27 publications presenting 35 different risk scales from the last 30 years. Most of them are multi-centrally validated studies. Due to lack of methodology, the authors rejected further 1100 publications.3 Statistically, more than one new scoring system appears each year. The authors of the meta-analysis conclude that it is unlikely that highly precise but also complicated (>30 variables) calculators would be preferred by clinicians. From their experience, scales of similar effectiveness, but simple and adapted to be used at bedside, have a better chance of being implemented in everyday practice.3

Despite the advantages of excellent accuracy and versatility, the use of the NSQIP SRC calculator takes too much time in the situation of staff limitations and the growing number of operations, especially if our goal is to evaluate each patient before each operation. NSQIP authors have left the possibility of omitting the patient’s risk factors in the calculation, which cannot be verified (difficult interview, no laboratory test results), but in this case, the prediction result may differ from the truth. With a large number of variables (>30), the probability of error grows exponentially. Glance et al tried to solve this problem by bringing the variables required for estimation to a minimum. The S-MPM scale includes the key components of perioperative risk: patient-related risk factors, ASA PS, and operational risk, as the extent and urgency of surgery.

ASA As An Element Of S-MPM Score

It is widely accepted that the ASA classification is not very precise and ambiguous.9,10 It expresses a “good feeling” rather than an objective assessment. However, a “good feeling” can be very precise.11 In Hartling et al, the precision of the surgeon’s foreknowledge in the assessment of surgical outcomes proved to have higher sensitivity and specificity than the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) scale including pre- and intraoperative factors (“good feeling”: sensitivity 84.2%, specificity 88.1% vs POSSUM: sensitivity 42.1%, specificity 64.4%).11 This fact may be an answer to the question why the ASA scale correlates well with in-hospital and 30-day mortality, although it has not been designed for this purpose.12,13 The discriminating power of the ASA scale against mortality fluctuated in various studies between AUC = 0.59,14 0.81,15 0.89,16 and 0.93.17 In our material, the discriminating power expressed by AUC in the ROC test was AUC = 0.855 (95% CI: 0.834–0.877, p = 0.00001). This result confirms its usefulness in forecasting deaths.

On the ASA PS scale, one patient (eg, the third) receives patients who have both cardiac, pulmonary, and endocrine problems, but also patients who are only burdened with one of these diseases. The ASA scale therefore does not guarantee sufficient risk differentiation. The RCRI scale is more precise in this respect, as is the NSQIP calculator recommended in the current ESA/ESC 2014 guidelines.4 On the RCRI scale, the probability of major accident cardiac event (MACE) and death18 increases with the number of risk factors. Despite this, the discriminating power of the RCRI scale is weak in all-cause-mortality forecasting, as only about 30–45% of the deaths are due to cardiac reasons.2,19 This was confirmed by our own results, where the RCRI scale reached the average discriminatory capacity for in-hospital mortality (AUC = 0.751, 95% CI: 0.015–0.721, p = 0.00001).

Severity Of The Procedure As An Element Of S-MPM Score

By using the operation code, Glance et al performed a huge statistical work, creating subsets of treatments with similar risks. S-MPM authors have created their own model of empirical approach to data collection and division of surgical procedures into small, medium, and high risk. These procedures were classified into three categories according to logistic regression coefficients after adjustment to ASA PS and urgency of the disease. For this reason, in their work, for example, scout laparotomy has been included in the high-risk group, while it is traditionally included in the medium-risk group. In our center, the classification of the severity of surgery is based on the ESC/ESA guidelines, where operations are classified into three groups according to the risk of serious cardiovascular complications and death (<1.1–5, >5%).4 This may explain the differences in regression coefficients and OR for operational risk (own companion logic for medium-risk operations = 0.79 vs 1.25 in Glance and for high-risk operations = 0.91 vs 2.06 in Glance/own OR for medium-risk operations = 2.21 vs 3.5 u Glance and for high-risk operations = 2.5 vs 7.9 in Glance). For example, liver resection < 3 segments is included in the middle group and >2 segments to the high-risk group. Appendectomy belongs to the group of low operational risk. As the author himself admits, the classification of the severity of the S-MPM procedure is not intuitive and the surgeon using it must recalibrate the operational risk.

Other scoring systems, such as the British United Provident Association (BUPA) used in the Surgical Risk Score by Sutton et al, include a more complex division. BUPA divides operations into five categories, where, for example, appendectomy is included in the high-risk group.17 Modified John Hopkins surgical criteria, used by Donati et al, assume, for example, that cholecystectomy belongs to the medium-risk group. In our center, this is a low-risk procedure.15

As you can see, the criteria for qualifying procedures for specific operational risk groups are heterogeneous. It is important to carefully read the criterion used in the scale that we want to use. With the advancement of surgical technique, we observe a reduction in operational risk (eg, open surgery is currently performed laparoscopically, intravascularly). For this reason, it is necessary to regularly adjust existing risk scales in order to adapt them to rapidly changing realities.

The authors of S-MPM excluded from the analysis treatments under local anesthesia. We have included such treatments in our analysis because we are of the opinion that the mortality rate is influenced above all by the patient’s risk and the extent of the surgery, while the risk associated with the type of anesthesia goes to the second plane. The anesthetic risk associated with narcosis is negligible today (<1:20,000). Patients operated under local anesthesia were included in our study into the low risk of surgical.

The Urgency Of The Procedure As Element Of S-MPM Score

The urgency of the procedure is an important component of the risk. Found in the OR literature for urgent surgery, they are between 2.26 (95% CI: 0.8–6.4),15 2.5 (95% CI: 1.5–3.9),20 2.45 (95% CI: 1.65–3.25),21 4.6 (95% CI: 3.1–6.4),22 and 6.2 (95% CI: 4.43–8.66).23 After adjusting for the ASA PS status and operational risk, the urgent surgery involved a threefold increase in the risk of in-hospital death (OR = 2.99; 95% CI: 2.32–3.85). This is a result similar to the results of Glance et al (OR for urgent surgery in S-MPM = 2.54). The S-MPM scale showed the best discrimination in general and traumatic surgery (see Table 8). For these two treatments, the AUC reached 0.89. In vascular surgery, the AUC of the S-MPM scale reached only 0.735 (95% CI: 0.677–0.792, p = 0.00001). This result reflects the specific risk profile of patients in this group. A similar result in our study reached ASA (AUC in vascular density = 0.072, 95% CI: 0.722–0.823) and RCRI (AUC in vascular density = 0.745, 95% CI: 0.69–0.8). This result is not a surprise, because as it is known, the RCRI scale does not take into account non-cardiac causes and is not suitable for the estimation of all-cause-mortality.22 The accusation in the readers’ letters about the S-MPM scale that insufficient consideration of the nature of individual surgical disciplines is illustrated by the mortality diagram in vascular, general and traumatic surgery in S-MPM classes (class I–III).24 These discrepancies can be easily mitigated by adjusting the logistic regression coefficients to a given field, as it was done, for example, for the Vascular-POSSUM (V-POSSUM) scale.25,26 In this way, not one universal but several specific S-MPM scales will be created, without complicating this tool (eg, Vasc-S-MPM, Trauma-S-MPM). The difference would be only to change the score given to given S-MPM risk factors on the basis of specifically calculated regression coefficients.

Practical Use Of The Prediction Tools

Glance also admits that the use of accurate tools, including specific types of operations, specific diseases, such as the National Surgical Quality Improvement Program Surgical Clinical Reviewer (NSQIP SRC) calculator, is justified in the face of current widespread and easy access to computers/smartphones. Complicated mathematical calculations are automatically performed.24 However, in our opinion, it is not the availability of a computer that is a key problem. Most calculators are available in a mobile form and can be used always and everywhere at the patient’s bedside. The real problem is the time required to enter a large number of variables. Glance et al obtained the data from the NSQIP program resources. The integrity of the data is guaranteed by a system in which people specially trained for this purpose deal with the completion of data on research, interview, and conduct telephone surveys with patients after discharge. Therefore, these were high-quality data. This is evidenced by the good result of the S-MPM scale validated by us. Administration data are considered to be of low quality and maybe the reason for the poor accuracy of the scale created on their basis.24

In the case of our data, the characteristics of the administration had only information about the hospital’s death in the patient. All other information, such as ASA classification, cardiology, endocrinology, pulmonology, exercise capacity, and current pharmacotherapy are collected during anesthesiological preparation in a systematic premedication program by colleagues of anesthesiologists. These data are independent of the coding quality in the Diagnosis-Related Group system as is the case for administrative data.


The S-MPM scale by Glance et al has proven to be a useful tool to assess the risk of in-hospital death and can be taken into account when considering treatment indications, patient information, planning post-operative care and quality control.


A simple nine-point S-MPM scale achieved a good discriminating power and a perfect fit in the entire population studied, with particular emphasis on general and traumatic surgery. In vascular surgery her discriminating power was weak. We are of the opinion that the authors of the S-MPM scale managed to achieve the intended goal of creating a tool that is quite accurate and at the same time uncomplicated.

In the future, one would be tempted to design several varieties of the S-MPM scale addressed to specific surgical disciplines.

Consent Of The Bioethics Committee

There is no need to obtain the consent of the Bioethics Committee in the following situations in Germany and applies to our institution HELIOS Hospital in Berlin-Buch.

  • (1) Quality assurance activities without research objective.
  • (2) Analysis of anonymized retrospective data, meaning that existing data from a patient file without name, address or date of birth are analyzed. This means that it is no longer possible to assign a data file to a specific patient file at a later date.
  • Abbreviations

    S-MPM, Surgical Mortality Probability Model; AUC, area under curve; HL test., Hosmer–Lemeshow test; ASA, American Society of Anesthesiology; RCRI, Revised Cardiac Risk Index; ESC, European Society of Cardiology; ESA, European Society of Anesthesiology; ACS-NSQIP, American College of Surgeons-National Surgical Quality Improvement Program; NSQIP, National Surgical Quality Improvement Program; NSQIP SRC, National Surgical Quality Improvement Program Surgical Clinical Reviewer; HIS, Hospital Information System; PCCL, Patient Clinical Complexity Level; BUPA, British United Provident Association; OR, odds ratio; ASA, American Society of Anesthesiology; ASA PS, American Society of Anesthesiologists physical status; V-POSSUM, Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity; Vasc-S-MPM, Vascular-Surgical Mortality Probability Model; Trauma-S-MPM, Trauma-Surgical Mortality Probability Model; SRC, Surgery Risk Calculator; DRG, Diagnosis-Related Group; IR, interval; CHF, congestive heart failure; MI, myocardial infarction; AF, atrial fibrillation; CPR, cardio-pulmonary resuscitation; PAD, peripheral artery disease; TIA, transient ischemic attack; PTCA, percutaneous transluminal coronary angioplasty; CABG, coronary Artery Bypass Graft; COPD, chronic obstructive pulmonary disease; DM, type 2 diabetes mellitus; IDDM, insulin-dependent diabetes mellitus; NIDDM, non-insulin-dependent diabetes; liver cirrhosis, cirrhosis of any Child-Pugh level; HS, length of hospitalization; HS before OP, length of stay before surgery; Total Time OP, total time of durations of operations; CI, confidence interval; ROC, receiver operation curve; MACE, major accident cardiac event; Crude OR, odds ratio in univariate regression analysis; adj. OR, odds ratio after adjustment relative to the rest of explanatory variables in the multivariate regression analysis.


    The weakness of our study is the fact that we did not have the data needed to determine the suitability of the S-MPM scale to predict death within 30 days of surgery. Also, the classification of the severity of surgical procedures was not consistent with that used in the original work. One should remember about an additional problem regarding every scale trying to predict mortality and morbidity based on pre-operative data. An escalation of the surgery that cannot be predicted raises the actual risk compared to the risk that was estimated taking into account the original plan/scope of the operation. The retrospective nature of our study from the routine data excludes the possibility of creating various types of adulteration (“bias”). This fact speaks in favor of the tested scale, which worked well in the conditions of everyday routine in the external center. An ambiguous way of qualifying surgery for three risk classes, another in Glance’s work and in our study, did not significantly reduce the suitability of this scale to assess the risk of in-hospital death.

    Data Availability

    The first author has the data supporting the results reported in the manuscript and will make them available at the editor’s or readers’ request.

    Author Contributions

    All the authors approve of the version of the manuscript to be published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of the work are appropriately investigated and resolved. The specific contributions (conditions 1 and 2) of the authors is as follows:

    Sebastian Kazimierczak: the conception and design of the work; the acquisition, analysis, and interpretation of data for the work; drafting the work. Anita Rybicka: the acquisition, analysis, and interpretation of data for the work; drafting the work. Jochen Strauss: the design of the work; the interpretation of data for the work; revising the work critically for important intellectual content. Malgorzata Schram: the acquisition and analysis of data for the work; drafting the work. Arkadiusz Kazimierczak: the conception or design of the work; the analysis and interpretation of data for the work; drafting the work. Elżbieta Grochans: the analysis and interpretation of data for the work; revising the work critically for important intellectual content.


    The authors declare no competing interests of any kind in this work.


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