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Exacerbation Frequency And Eosinophil Counts Among Patients With COPD Currently Prescribed Triple Therapy

Authors Benson VS, Pascoe KC, Siddall J, Small M, Müllerová H

Received 28 May 2019

Accepted for publication 31 October 2019

Published 29 November 2019 Volume 2019:14 Pages 2711—2723


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Victoria S Benson,1 Katie C Pascoe,1 James Siddall,2 Mark Small,2 Hana Müllerová1

1GSK, Research and Development Uxbridge, Uxbridge, UK; 2Adelphi Real World, Adelphi Mill, Bollington, UK

Correspondence: Victoria S Benson
GSK, Stockley Park West, 1-3 Ironbridge Road, Uxbridge, Middlesex UB11 1BT, UK
Tel + 44 20 89903306

Purpose: To characterize and estimate the proportion of patients with chronic obstructive pulmonary disease (COPD) who continue to exacerbate while receiving triple therapy and further describe these patients according to blood eosinophil counts.
Methods: This was an analysis of the 2017 Adelphi Real-World Respiratory Disease Specific Programme (DSP) survey of patients with COPD from France, Germany, Italy, Spain, and the United Kingdom (UK). Demographics were assessed on the date of completion of the physician/patient questionnaire; clinical characteristics were captured for the previous 12 months. The proportion of patients receiving triple therapy, who had experienced ≥2 moderate or ≥1 severe acute exacerbations of COPD (AECOPD) in the 12 months prior to index, and had blood eosinophil counts ≥150 cells/μL (T-AECOPD-EOS150) or ≥300 cells/μL (T-AECOPD-EOS300), were calculated.
Results: In total, 2876 patients were included of which 762 had an eosinophil value. A higher proportion of patients in the ≥300 cells/μL eosinophil group (55.9%) compared with 150–Conclusion: This analysis demonstrates that there is a subpopulation of patients with COPD who continue to experience exacerbations despite receiving triple therapy; approximately three-quarters of these had eosinophils ≥150 cells/μL and one-third had eosinophils ≥300 cells/μL; these patients may benefit from eosinophil-targeted therapies.

Keywords: blood eosinophil, healthcare resource, targeted therapy, disease burden, respiratory

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