Evaluation of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury
Authors El-Hofi AH, Helaly HA
Received 26 October 2018
Accepted for publication 9 January 2019
Published 18 February 2019 Volume 2019:13 Pages 383—390
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Justinn Cochran
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Abdel Hamid El-Hofi, Hany Ahmed Helaly
Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Purpose: To evaluate the outcome of limbal transplantation in eyes with bilateral severe ocular surface damage secondary to chemical injury.
Patients and methods: This was a retrospective case series that included 20 patients who had undergone living related limbal transplantation due to the presence of bilateral severe stem cell deficiency resulting from chemical injury. Medical records of the selected patients were reviewed. The following data were recorded and analyzed: gender; age at the time of the surgery; duration of follow-up; corrected distance visual acuity (CDVA); symptoms; intraocular pressure (IOP); any complications; postoperative treatment; and other surgical procedures needed.
Results: The mean age of the included patients was 27.4±9.3 years. The causative agent was an alkali in 14 patients. Fifteen patients (75%) had a stable ocular surface (ie, complete corneal re-epithelization and resolution of postoperative inflammation) after the first limbal transplantation, while the other five patients (25%) needed regrafting. As regards the IOP; five patients (25%) needed Ahmed’s valve implantation to control the IOP. Other surgical procedures needed were penetrating keratoplasty (PKP) in three patients (15%), cataract surgery in six patients (30%), and lid surgery in one patient (5%).
Conclusion: In conclusion, living related conjunctival limbal allograft transplantation, especially when combined with amniotic membrane transplantation, yielded good results in the management of cases with bilateral severe chemical eye injuries.
Keywords: living related, limbal stem cells, transplantation, chemical injury
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