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Evaluation of Abortifacient Effect of Rumex nepalensis Spreng Among Pregnant Swiss Albino Rats: Laboratory-Based Study

Authors Dabe NE, Kefale AT, Dadi TL

Received 30 April 2020

Accepted for publication 19 June 2020

Published 31 July 2020 Volume 2020:12 Pages 255—265

DOI https://doi.org/10.2147/JEP.S260719

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Bal Lokeshwar


Video abstract presented by Nikodimos Eshetu Dabe.

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Nikodimos Eshetu Dabe,1 Adane Teshome Kefale,2 Tegene Legese Dadi3

1Department of Biomedical Science, College of Health Sciences, Mizan–Tepi University, Mizan Teferi, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 3Department of Public Health, College of Health Sciences, Mizan–Tepi University, Mizan Teferi, Ethiopia

Correspondence: Nikodimos Eshetu Dabe Email nixon.eshetu@gmail.com

Background: Rumex nepalensis Spreng (Amharic: Yewsha Tult) belongs to the Polygonaceae (buckwheat) family. In Ethiopia, the plant is traditionally used for the treatment of stomach ache, tonsillitis, ascariasis, uterine bleeding, etc. An ethnobotanical study from Mizan–Tepi University also reported the use of the plant by “Shekicho” people as an abortifacient. As a result, this study aimed at the assessment of the outcome of hydro-ethanolic leaves extract of R. nepalensis on Swiss albino pregnant rats and confirm its abortifacient activity.
Methods: The hydro-alcoholic leaves extract of Rumex nepalensis Spreng was evaluated for its abortifacient activity in Swiss albino rats. The mature female rats were mated overnight to male rats in mating cages. Two different dosage regimens (300 mg/kg, 600 mg/kg) of the extract were administered. Laparotomy was performed on the rats to assess the uterus and ovary, the viable, non-viable, adsorbing sites, and corpora lutea. Differences between the experimental and control groups were compared using one-way analysis of variance (ANOVA), followed by Dunnett’s T-test to determine their level of significance.
Results and Discussion: This study revealed that Rumex nepalensis Spreng had anti-implantation and abortifacient activities at both 300 and 600 mg/kg doses, which was statistically significant as compared with the controls. It was relatively safe up to the dose of 5000 mg/kg, where no mortality and organ toxicity were manifested. Phytochemicals identified were alkaloids, flavonoids, saponins, tannins, steroids, and anthraquinones.
Conclusion: In general, our study showed that R. nepalensis had a significant abortifacient activity that testifies its traditional dibs. Therefore, the use of this plant should be avoided in pregnant women to minimize unintended abortion and further studies are needed to know its mechanism of activity and to identify the phytochemicals corresponding to this activity. Checking its efficacy on other species is also needed.

Keywords: Rumex nepalensis Spreng, traditional medicine, abortifacient activity

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