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Epidemiology, microbiology, and treatment patterns of pediatric patients hospitalized with pneumonia at two hospitals in China: a patient chart review study

Authors Wen Z, Wei J, Xue H, Chen Y, Melnick D, Gonzalez J, Hackett J, Li X, Cao Z

Received 6 June 2017

Accepted for publication 28 October 2017

Published 13 March 2018 Volume 2018:14 Pages 501—510

DOI https://doi.org/10.2147/TCRM.S143266

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Hoa Le

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang


Zehuai Wen,1 Jia Wei,2 Huiling Xue,2 Yunqin Chen,2 David Melnick,3 Jesus Gonzalez,4 Judith Hackett,5 Xiaoyan Li,1 Zhaolong Cao6

1Key Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 2AstraZeneca R&D Information China, Shanghai, China; 3Anti-Infectives Actavis, Inc. Harborside Financial Center, Jersey City, NJ, USA; 4AstraZeneca, Manchester, UK; 5AstraZeneca, Gaithersburg, MD, USA; 6Peking University People’s Hospital, Beijing, China

Background:
The etiology, epidemiology, treatment patterns, and clinical outcomes of neonatal and pediatric pneumonia patients in China are not well reported. This retrospective chart review study aimed to describe such information among neonatal (0 to 27 days) and pediatric (28 days to <18 years) pneumonia patients in two regions of China.
Methods: Electronic medical records of pneumonia hospitalizations (aged <18 years) admitted between 2008 and 2013 from four hospitals under Guangdong Provincial Hospital of Chinese Medicine (Southern China) and between 2010 and 2014 at Peking University People’s Hospital (Beijing, Northern China) were reviewed.
Results: The average age of neonatal hospitalizations in Beijing (n=92) was 3.5 days. The mean length of hospital stay was 11.2 days, and no deaths occurred. Staphylococcus epidermidis was the most common bacteria found in Beijing patients, whereas Mycoplasma pneumoniae was the most common bacteria found in Guangdong patients. The average age of pediatric hospitalizations was 3.3 (±3.1) and 6.5 (±5.6) years in Guangdong (n=3,046) and Beijing (n=222), respectively. The mean length of hospital stay was 17.4 and 5.8 days, and overall mortality rates were 0.2% and 0.5%.
Conclusion: The findings revealed a low level of bacterial isolation and hence microbiological diagnoses. There was a low level of in-hospital mortality due to pneumonia, and the majority of hospitalizations were discharged from hospital, suggesting that current practice was generally effective. Neonatal hospitalizations were greater than pediatric hospitalizations in Beijing along with disparity in bacterial profile when compared with Guangdong, intending a need to improve neonatal pneumonia prophylaxis and selection of appropriate treatment.

Keywords: pediatric, neonatal, pneumonia, epidemiology, microbiology, antibiotic therapy

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