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Epicrania fugax combining forward and backward paroxysms in the same patient: the first four cases

Authors Barón-Sánchez J, Gutiérrez-Viedma Á, Ruiz-Piñero M , Pérez-Pérez A, Guerrero ÁL , Cuadrado ML

Received 28 February 2017

Accepted for publication 17 May 2017

Published 23 June 2017 Volume 2017:10 Pages 1453—1456

DOI https://doi.org/10.2147/JPR.S135810

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor E Alfonso Romero-Sandoval



Johanna Barón-Sánchez,1 Álvaro Gutiérrez-Viedma,2 Marina Ruiz-Piñero,1 Alicia Pérez-Pérez,2 Ángel Luis Guerrero,1,3 María L Cuadrado2,4

1Headache Unit, Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; 2Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain; 3Department of Medicine, School of Medicine, Universidad de Valladolid, Valladolid, Spain; 4Department of Medicine, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

Background: The first description of epicrania fugax (EF) reported brief painful paroxysms that start in posterior regions of the scalp and move forward to reach the ipsilateral forehead, eye, or nose. A backward variation, wherein pain stems from frontal areas and radiates to the posterior scalp, has also been acknowledged. We report four patients with features reminiscent of EF and the coexistence of forward and backward pain paroxysms.
Methods: We considered all patients attending the headache outpatient office at two tertiary hospitals from March 2008 to March 2016. We enrolled four patients with paroxysms fulfilling criteria for EF and a combination of forward and backward radiations.
Results: In all cases, pain paroxysms moved both in forward and backward directions with either a zigzag (n=2) or linear (n=2) trajectory. Three patients presented two stemming points, in the occipital scalp and forehead (n=2) or in the parietal area and eye (n=1), whereas the fourth patient only had a stemming point located in the parietal region. Pain quality was mainly stabbing, and its intensity was moderate (n=1) or severe (n=3). The duration of the paroxysms was highly variable (3–30 seconds), and two patients reported autonomic symptoms.
Conclusion: The clinical picture presented by our patients does not fit with other types of known headache or neuralgia syndromes; we propose it corresponds to a bidirectional variant of EF.

Keywords: epicrania, epicranial neuralgias, backward radiation, forward radiation

 

Introduction

Epicrania fugax (EF) is a recently described headache syndrome.1 It has been classified as a primary headache in the research Appendix of the 3rd edition of the International Classification of Headache Disorders (ICHD-III, beta version).2 EF is characterized by the occurrence of brief pain paroxysms moving along a hemicranium between two distant points through the territories of different nerves. The intensity of pain can be moderate or severe, and its quality has been mainly described as electric or stabbing. In some cases the pain is accompanied by autonomic signs such as conjunctival injection, lacrimation, or rhinorrhea. Between the paroxysms, a slightly painful sensation may persist at the stemming point. Pain frequency is highly variable. Most pain attacks are spontaneous, but some of them can be triggered by tactile stimulation1,3 or with cranio- or orofacial movements.4

Initial descriptions depicted a unilateral pain spreading from posterior cranial areas to the ipsilateral anterior scalp, following a linear or zigzag trajectory – that is the classical forward EF.1,5 Later on, a backward EF – with pain radiating from frontal areas toward the posterior scalp – was also described, with no demographic or clinical differences between both variants.68 The phenotype of EF has become even broader during the last few years. For instance, it has been reported that pain paroxysms may occur at shifting sides,1,7 along the mid-sagittal plane,9 with coronal radiation10 or even in a multidirectional fashion.11 A facial variant of EF4 has also been proposed.

We aim to report four new patients who fulfill EF diagnostic criteria, and present both forward and backward pain paroxysms.

Methods

We retrospectively considered all patients attending the headache outpatient office at two tertiary hospitals (Hospital Clínico Universitario, Valladolid, and Hospital Clínico San Carlos, Madrid) from March 2008 to March 2016. We selected four patients in whom pain paroxysms moved with both forward and backward radiation. Patients were referred either from primary physicians or general neurology offices; we selected cases among those describing brief and dynamic pain paroxysms. In each case, we considered both demographic and clinical characteristics, including location of the stemming and ending points, pain trajectory, pain quality, pain intensity, accompaniments, and triggers. Neurological examination was unremarkable in all patients, and magnetic resonance imaging (MRI) and laboratory tests were performed in all cases to exclude underlying diseases. Written, informed consent to publish the case details was provided by the patients in this report and has also been obtained from the authors (ALG and MLC). This study was approved by the Research Committee of Hospital Clínico Universitario de Valladolid.

Results

Patient 1

A 71-year-old woman with a history of menstrual-related migraine was assessed due to a 1-year history of a new type of headache. Pain paroxysms stemmed at the right parietal scalp and spread in a zigzag trajectory, both forwards and backwards, to reach the ipsilateral eye after 1 second and the suboccipital region in 3 seconds (Figure 1A). Pain quality was described as electric, and its intensity was rated as 8 out of 10 on a visual analog scale (VAS; 0: no pain, 10: the worst imaginable pain). The headache was consistently associated with ipsilateral ptosis, lacrimation, and conjunctival injection. These pain paroxysms appeared from one to countless times throughout the day, with an average frequency of four times per day. A mild interictal pain in a non-circumscribed area persisted over the stemming point. These paroxysms could not only be triggered by touching the parietal scalp but also occurred spontaneously. Physical examination showed hypersensitivity upon palpation of the right parietal scalp. Gabapentin (300 mg bid) was prescribed with marked improvement.

Figure 1 Trajectory of pain paroxysms in our four patients. (A) Parietal to occipital area and parietal area to the eye (right side). (B) Occipital area to the forehead (right and left sides). (C) Occipital area to the forehead (left side). (D) Parietal area to the eye (right side).

Patient 2

A 42-year-old man with no relevant medical history came to our office due to a 5-year history of pain paroxysms along both hemicrania. Approximately 70% of these paroxysms radiated in a lineal trajectory from the occipital scalp to the ipsilateral forehead, whereas 30% moved from the forehead to the ipsilateral occipital region. Most of the paroxysms (80%) were located on the right hemicranium, but a minority (20%) occurred on the left side (Figure 1B). Pain quality was described as stabbing, and pain intensity was rated as 8 out of 10 on a VAS. The attacks lasted 5 seconds and were infrequent (2–3 times a week). There were no associated symptoms. The patient did not report other interictal tenderness or pain triggers. Lamotrigine 100 mg bid was prescribed, leading to substantial pain relief.

Patient 3

A 21-year-old woman with prior history of migraine with visual aura started suffering a new type of headache 1 year before assessment. She complained of two paroxysms per week comprising a stabbing pain moving with a linear trajectory between the left occipital region and the ipsilateral forehead lasting for 20 seconds. Approximately 90% of the paroxysms radiated backwards, but 10% had forward radiation (Figure 1C). Pain intensity was rated as 6 out of 10 on a VAS. All of these attacks were associated with ipsilateral lacrimation. The patient did not report any precipitating factors and described no pain during interictal periods. Lamotrigine 100 mg bid was recommended, but adherence to therapy was incomplete.

Patient 4

A 57-year-old woman with no prior headaches presented with an 8-month history of paroxysmal pain. In most instances (90%), the pain started over the right parietal scalp and moved in a zigzag manner to the ipsilateral eye. Yet, 10% of the episodes had backward radiation from the right eye to the ipsilateral occipital region (Figure 1D). The pain was described as stabbing and extremely severe (10 out of 10). Attacks lasted approximately 30 seconds, and there were no accompanying symptoms. Paroxysms were more frequent at night and occurred three times a week. The patient reported neither interictal pain nor tenderness. Treatment with amitriptyline (10 mg q.d.) was only partially effective.

Discussion

We describe four new patients with characteristics considered distinctive of EF. Each of them presented with bidirectional paroxysms of pain, with the pain moving both forwards and backwards. Forward and backward paroxysms could occur at the same time (Patient 1) or in different attacks (Patients 2–4). Pain quality and intensity, as well as the radiation with a linear or zigzag trajectory, did not depend on the direction of the pain. The duration of the attacks was variable, between 3 and 30 seconds. In two of the cases (Patients 1 and 3), the pain was associated with autonomic signs. Between attacks, one patient (Patient 1) had mild pain and tenderness at the stemming area.

The clinical picture of EF has been described as a combination of static and dynamic components. Pain paroxysms run between the posterior scalp (C2) and the frontal or periorbital area (V1), either in a forward or a backward direction. With regard to the static component, the stemming area can be slightly painful between the paroxysms (12). In the facial variant of EF, pain starts in the face (dermatomes V2 or V3).4

The etiology of EF remains unknown, although clinical characteristics such as stabbing character of the pain and the presence of a stemming area suggest an epicranial source.12 It has been proposed that the pain may start at the terminal branches of the pericranial nerves and that pain spreads due to different mechanisms, such as aberrant ephaptic transmission connecting different nerve fibers, involvement of transdiploic fibers,1 or recruitment of central mechanisms.12

The static component of EF has been related to the area in which the pain initiates. This baseline pain has been more frequently described among patients with forward radiation, than in those with backward variant. We have also observed in some cases an interictal pain in the area in which pain paroxysms end (data not published). Similarly as a nummular headache may be located in different scalp areas in the same patient,13 peripheral generators of EF may be located in anterior or posterior regions,12 as happened in three of our cases. In our opinion, therefore, it is not surprising to have the appearance of forward and backward radiations in the same patient as described in this series.

Conclusion

The patients in our series fulfilled diagnostic criteria of EF, with a paroxysmal pain that manifested in two directions (forward and backward) in the same patient at different times or simultaneously. This description expands the clinical spectrum of EF and further clarifies the differential diagnosis between EF and pericranial neuralgias.

Acknowledgments

The abstract of this paper was presented at the 2nd Congress of the European Academy of Neurology as a poster presentation with interim findings. The poster’s abstract was then published in the European Journal of Neurology. vol 23, June 2016.

Disclosure

The authors report no conflicts of interest in this work.

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