Back to Journals » Therapeutics and Clinical Risk Management » Volume 15

Eosinophilic Pneumonia Associated With Natalizumab In A Patient With Multiple Sclerosis: A Case Report And Literature Review

Authors Yasuda Y, Nagano T, Tachihara M, Chihara N, Umezawa K, Katsurada N, Yamamoto M, Sekiguchi K, Kobayashi K, Nishimura Y

Received 2 August 2019

Accepted for publication 27 September 2019

Published 1 November 2019 Volume 2019:15 Pages 1283—1289

DOI https://doi.org/10.2147/TCRM.S225832

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Yuichiro Yasuda,1 Tatsuya Nagano,1 Motoko Tachihara,1 Norio Chihara,2 Kanoko Umezawa,1 Naoko Katsurada,1 Masatsugu Yamamoto,1 Kenji Sekiguchi,2 Kazuyuki Kobayashi,1 Yoshihiro Nishimura1

1Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan; 2Division of Neurology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan

Correspondence: Tatsuya Nagano
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Kobe, Hyogo 650-0017, Japan
Tel +81-783-82-5660
Fax +81-783-82-5661
Email tnagano@med.kobe-u.ac.jp

Abstract: We herein report the case of a 39-year-old Japanese female with eosinophilic pneumonia associated with natalizumab. The patient with bronchial asthma had multiple sclerosis and was treated using natalizumab. The patient was referred to our department because of a persistent cough. A chest computed tomography (CT) scan revealed bilateral patchy consolidation surrounded by ground-glass opacity. A bronchoalveolar lavage (BAL) was performed. Eosinophil levels in the BAL fluid were increased and the patient was consequently diagnosed as eosinophilic pneumonia associated with natalizumab. Therefore, natalizumab treatment was discontinued. Subsequent chest CT findings showed a remarkable improvement without any treatment.

Keywords: eosinophilic pneumonia, natalizumab, multiple sclerosis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]