Back to Journals » Clinical Ophthalmology » Volume 5

Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding

Authors Kim J, Do H, Egbert P

Published 24 November 2011 Volume 2011:5 Pages 1655—1658


Review by Single anonymous peer review

Peer reviewer comments 2

Jonathan Kim1, Huy Do2, Peter Egbert1
1Department of Ophthalmology, Stanford Medical Center, Palo Alto, CA, USA; 2Department of Interventional Neuro-radiology, Stanford Medical Center, Stanford, CA, USA

Abstract: Selective intra-arterial chemotherapy (IAC) has been adopted by many ocular oncology centers to treat advanced intraocular retinoblastoma. In this report, we describe two patients with unilateral intraocular retinoblastoma and persistent vitreous seeding, who were treated with IAC after failed systemic chemotherapy. Despite multiple sessions and increasing dosage of drug delivery, vitreous seeding in these cases failed to respond to IAC, and ultimately both eyes were enucleated for tumor control. Based on the histopathologic findings in these two cases, IAC appears to have limitations in treating persistent vitreous seeding in eyes which have failed systemic chemotherapy. Possible causes for failure of IAC to treat persistent vitreous seeding include poor vitreous penetration, inactive state of tumor seeds within the avascular vitreous cavity, and chemotherapeutic drug resistance.

Keywords: chemotherapy, retinoblastoma, intra-arterial, failure, enucleation, eye

Creative Commons License © 2011 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.