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Endothelial repair capacity and apoptosis are inversely related in obstructive sleep apnea

Authors Jelic S, Lederer DJ, Adams T, Padeletti M, Colombo PC, Factor P, Le Jemtel TH

Published 3 November 2009 Volume 2009:5 Pages 909—920

DOI https://doi.org/10.2147/VHRM.S8123

Review by Single-blind

Peer reviewer comments 4


Sanja Jelic1,  David J Lederer1, Tessa Adams1, Margherita Padeletti1, Paolo C Colombo2, Phillip Factor1, Thierry H Le Jemtel3

1Division of Pulmonary, Allergy, and Critical Care Medicine, 2Division of Cardiology, Columbia University College of Physicians and Surgeons, New York, NY, USA; 3Division of Cardiology, Tulane University School of Medicine, New Orleans, LA, USA

Purpose: To investigate the impact of obstructive sleep apnea (OSA) on endothelial repair capacity and apoptosis in the absence of potentially confounding factors including obesity.

Patients and methods: Sixteen patients with a body mass index <30 and newly diagnosed OSA and 16 controls were studied. Circulating levels of endothelial progenitor cells, a marker of endothelial repair capacity, and endothelial microparticles, a marker of endothelial apoptosis, were quantified before and after four-week therapy with continuous positive airway pressure (CPAP). Endothelial cell apoptotic rate was also quantified in freshly harvested venous endothelial cells. Vascular reactivity was measured by flow-mediated dilation.

Results: Before treatment, endothelial microparticle levels were greater and endothelial progenitor cell levels were lower in patients with OSA than in controls (P < 0.001 for both). Levels of endothelial microparticles and progenitors cells were inversely related (r = -0.67, P < 0.001). Endothelial progenitor cell levels increased after effective treatment (P = 0.036).

Conclusions: In the absence of any co-morbid conditions including obesity, OSA alone impairs endothelial repair capacity and promotes endothelial apoptosis. These early endothelial alterations may underlie accelerated atherosclerosis and increased cardiovascular risk in OSA.

Keywords: sleep apnea, endothelium, apoptosis, endothelial repair capacity

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