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Emerging treatment options for patients with recurrent advanced thymic epithelial tumors

Authors Evans T

Received 17 April 2012

Accepted for publication 20 June 2012

Published 7 September 2012 Volume 2012:5 Pages 177—184

DOI https://doi.org/10.2147/OTT.S23267

Review by Single anonymous peer review

Peer reviewer comments 2

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Tracey L Evans

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

Abstract: The purpose of this review article is to review recent advances in the treatment of advanced thymic epithelial tumors. These tumors are generally responsive to cytotoxic combination chemotherapy in the first-line setting. While newer agents have shown efficacy in the salvage setting, there is no one standard approach. A multitude of targeted agents have shown promise generally in case reports, though as of yet, nothing has shown consistent benefit. Because of the rarity of thymic epithelial tumors, clinical trial enrollment is difficult but nevertheless essential.

Keywords: thymoma, thymic carcinoma, targeted therapy, epidermal growth factor receptor

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