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Emerging strategies in the treatment of poststroke depression and psychiatric distress in patients

Authors Capaldi II VF, Wynn GH

Published 6 December 2010 Volume 2010:3 Pages 109—118

DOI https://doi.org/10.2147/PRBM.S10035

Review by Single-blind

Peer reviewer comments 2


Vincent F Capaldi II1 Gary H Wynn2
1Department of Psychiatry, Walter Reed Army Medical Center, Washington, DC, USA; 2Department of Military Psychiatry, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA

Abstract: Poststroke depression (PSD) is a common sequela of stroke associated with increased morbidity and mortality among stroke survivors. PSD has been associated with poorer rehabilitative outcomes, longer inpatient stays, inefficient use of medical resources, worsened cognitive decline, and increased suicidality. This article reviews the definition and proposed etiology of PSD as well as current and emerging evidence-based prevention, screening, and treatment modalities. The timely use of prevention and treatment techniques including pharmacologic and nonpharmacologic methods may improve treatment outcomes and enhance the quality of life in stroke patients.

Keywords: poststroke depression, SSRI, TCA, stroke, CBT

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