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Embryonic–maternal cross-talk via exosomes: potential implications

Authors Saadeldin IM, Oh HJ, Lee BC

Received 19 March 2015

Accepted for publication 23 April 2015

Published 7 July 2015 Volume 2015:8 Pages 103—107

DOI https://doi.org/10.2147/SCCAA.S84991

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Bernard Binetruy

Islam M Saadeldin,1 Hyun Ju Oh,2 Byeong Chun Lee2,3

1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt; 2Department of Theriogenology and Biotechnology, College of Veterinary Medicine and the Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea; 3Institute of Green Bio Science and Technology, Seoul National University, Pyeong Chang, Kangwon do, Republic of Korea


Abstract: A myriad of locally produced factors into the microenvironment of the reproductive tract is regulated, not one-way but rather, through embryonic–maternal cross-talk. In this minireview, we focused on the exosomes, which are cell-derived vesicles of 30–100 nm in diameter, as a communicating language facilitating this dialog. These nanovesicles are secreted from preimplantation embryos, oviduct epithelium, and endometrium as well as from the placenta, and contain proteins, messenger RNA (mRNA), microRNA, and DNA cargoes, and have pleiotropic effects on both embryonic and maternal environments. A better understanding of the molecular mechanisms mediating this cross-talk will lead to the development of new regulating agents, with novel diagnostic, biological, and therapeutic potential for either supporting or hindering the normal reproductive functions.

Keywords: embryo, endometrium, placenta, mRNA, miRNA

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