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Egyptian Propolis-Loaded Nanoparticles as a Root Canal Nanosealer: Sealing Ability and in vivo Biocompatibility

Authors Abdel Raheem IA, Abdul Razek A, Elgendy AA, Labah DA, Saleh NM

Received 19 April 2020

Accepted for publication 8 July 2020

Published 27 July 2020 Volume 2020:15 Pages 5265—5277

DOI https://doi.org/10.2147/IJN.S258888

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo


Islam Ali Abdel Raheem,1 Amro Abdul Razek,1 Abeer Abdelaziz Elgendy,1 Doaa Ahmed Labah,2 Noha Mohamed Saleh3

1Endodontics Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt; 2Oral Biology and Dental Medicine Department, Faculty of Dentistry, Zagazig University, Zagazig, Egypt; 3Pharmaceutics Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Correspondence: Noha Mohamed Saleh Email nunu_ramy@yahoo.com

Background: Successful endodontic therapy is mainly governed by the satisfactory sealing ability of the applied root canal sealer. Also, tolerability of root canal structure to accommodate the presence of a sealer participates in the efficiency of the treatment. Hence, this study was aimed to extrapolate our previous one that was concerned with the preparation and evaluation of novel nature-based root canal sealers. Our current work is focused on the evaluation of sealing ability and in vivo biocompatibility.
Materials and Methods: Egyptian propolis was extracted (ProE) and encapsulated in polymeric nanoparticles (ProE-loaded NPs). Two root sealers, PE sealer and PE nanosealer, were fabricated by incorporating ProE and ProE-loaded NPs, respectively. The sealing ability of the developed sealers was tested by a dye extraction method. An in vivo biocompatibility study was conducted using a subcutaneous implantation method for two and four weeks. At the same time, a model sealer (AH Plus®) was subjected to the same procedures to enable accurate and equitable results.
Results: The teeth treated with PE sealer exhibited weak sealing ability which did not differ from that of unfilled teeth. PE nanosealer enhanced the sealing ability similarly to the model sealer with minimal apical microleakage. Studying in vivo biocompatibility indicated the capability of the three tested sealers to induce cell proliferation and tissue healing. However, PE nanosealer had superior biocompatibility, with higher potential for cell regeneration and tissue proliferation.
Conclusion: PE nanosealer can be presented as an innovative root canal sealer, with enhanced sealing ability as well as in vivo biocompatibility. It can be applied as a substitute for the currently available sealers that demonstrate hazardous effects.

Keywords: propolis, nanoparticles, root sealer, sealing ability, dye extraction, biocompatibility, subcutaneous implantation

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