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Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses

Authors Versura P, Profazio V, Balducci N, Campos EC

Published 17 September 2010 Volume 2010:4 Pages 1035—1041


Review by Single-blind

Peer reviewer comments 5

Piera Versura, Vincenzo Profazio, Nicole Balducci, Emilio C Campos
Ophthalmology Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy

Purpose: To evaluate the efficacy and tolerability of Xiloial® monodose eyedrops in the treatment of patients suffering from subjective symptoms of discomfort related to disposable soft contact lens (dSCL) wear.
Methods: Fifteen (12 female, three male, medium age 39 ± 9 years) dSCL wearers were enrolled. Inclusion criteria were Ocular Surface Disease Index (ODSI) symptom questionnaire score >12, tear film break-up time (TFBUT) <10 sec, Schirmer test I >10 mm over five minutes, mild punctuate keratopathy, and conjunctival staining (Oxford grading ≤4). Monodose Xiloial eyedrops were administered three times daily for a two-month period. Patients were evaluated at enrollment, after three days of washout (baseline), and after one and two months of treatment, by OSDI score, Schirmer test I, TFBUT, ferning test, ocular surface damage (Oxford grade), and serum albumin in tears (index of passive exudation related to serum leakage).
Results: At endpoint versus baseline, respectively, the mean ± standard deviation of all variables improved as follows: OSDI (8.5 ± 3 versus 20.2 ± 1.6); TFBUT (9.6 ± 1.1 versus 7.1 ± 1.0); Oxford grading (0.5 ± 0.1 versus 3.6 ± 0.8); ferning test (2 ± 1 versus 2.4 ± 0.5); and Schirmer test I (14.6 ± 1.1 versus 12 ± 2.1), with P < 0.05 for all variables (Friedman and Wilcoxon tests). Tolerability was high, with no adverse events noted.
Conclusions: A two-month treatment with Xiloial showed good tolerance and appeared to reduce ocular surface damage and symptoms of discomfort.

Keywords: discomfort, dry eye, disposable contact lens, biopolymer tamarind seed polysaccharide–hyaluronic acid

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Other article by this author:

One month use of Systane® improves ocular surface parameters in subjects with moderate symptoms of ocular dryness

Piera Versura, Vincenzo Profazio, Emilio C Campos

Clinical Ophthalmology 2008, 2:629-635

Published Date: 12 September 2008

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