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Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination

Authors Rashad M 

Received 9 June 2012

Accepted for publication 3 September 2012

Published 28 December 2012 Volume 2013:7 Pages 15—22


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Mohammad A Rashad

Ophthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Purpose: To evaluate the success rate of a modified bleb needling technique in eyes with previous glaucoma surgery that had elevated intraocular pressure.
Methods: A retrospective study of 24 eyes of 24 patients that underwent repeated bleb needling performed for failing and failed blebs on slit lamp with 5-fluorouracil (5-FU) injections on demand. This was performed after gonioscopic examination to define levels of filtration block.
Results: There was significant reduction of mean IOP from 36.91 mmHg to 14.73 mmHg at the final follow-up (P < 0.001). The overall success rate was 92%.
Conclusion: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to revive filtration surgery rather than another medication or surgery.

Keywords: bleb, failure, 5-FU, needling, gonioscopy

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