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Efficacy and Safety of Secukinumab in Elderly Patients with Moderate to Severe Plaque-Type Psoriasis: Post-Hoc Analysis of the SUPREME Study
Authors Talamonti M , Russo F , Malara G, Hansel K, Papini M , Cattaneo A, Parodi A, Chiricozzi A , Malagoli P, Bardazzi F, Brazzelli V, Dapavo P, Gisondi P , Zane C, Potenza C, Cantoresi F, Fargnoli MC , Trevisini S, Brianti P, Pescitelli L, Gigante G, Bartezaghi M, Caputo L, Aloisi E, Costanzo A
Received 13 December 2022
Accepted for publication 21 March 2023
Published 1 April 2023 Volume 2023:16 Pages 847—852
DOI https://doi.org/10.2147/CCID.S400520
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Anne-Claire Fougerousse
Marina Talamonti,1 Filomena Russo,2 Giovanna Malara,3,4 Katharina Hansel,5 Manuela Papini,6 Angelo Cattaneo,7 Aurora Parodi,8 Andrea Chiricozzi,9,10 Piergiorgio Malagoli,11 Federico Bardazzi,12 Valeria Brazzelli,13 Paolo Dapavo,14 Paolo Gisondi,15 Cristina Zane,16 Concetta Potenza,17 Franca Cantoresi,18 Maria Concetta Fargnoli,19 Sara Trevisini,20 Pina Brianti,21 Leonardo Pescitelli,22 Giovanni Gigante,23 Marta Bartezaghi,23 Luisa Caputo,23 Elisabetta Aloisi,23 Antonio Costanzo24,25 On behalf of the SUPREME Study Group
1Dermatology, University of Rome Tor Vergata, Rome, Italy; 2Department of Medical, Surgical and Neurological Science, Dermatology Section, University of Siena, S. Maria alle Scotte Hospital, Siena, Italy; 3Dermatology Unit, Hospital “Bianchi Melacrino Morelli”, Reggio, Calabria, Italy; 4Department of Dermatology, Papardo Hospital, Messina, Italy; 5Section of Dermatology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 6Dermatologic Clinic of Terni, Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 7U.O. Dermatologia, Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milano, Italy; 8Di.S.Sal. Section of Dermatology, Ospedale Policlinico San Martino, University of Genova, Genova GE, 16132, Italy; 9UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy; 10Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; 11Psocare Unit, I.R.C.C.S Policlinico San Donato, Milano, Italy; 12Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 13Dermatology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy; 14Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Torino, Torino, Italy; 15Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy; 16Dermatology Department, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy; 17Dermatology Unit “Daniele Innocenzi”, Department of Medico-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome – Polo Pontino, Latina, Italy; 18Dermatology Unit, Department of Medicine, University of Roma, Roma, Italy; 19Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 20Department of Dermatology, University of Trieste, Trieste, Italy; 21Dermatology and Cosmetology Unit - San Raffaele Hospital, Milan, Italy; 22Department of Health Sciences, Dermatology Clinic, University of Firenze, Firenze, Italy; 23Novartis Farma SpA, Origgio, Italy; 24Unit of Dermatology, IRCCS Humanitas Research Hospital, Milano, Italy; 25Department of Biomedical Sciences, Humanitas University, Milano, Italy
Correspondence: Marina Talamonti, Dermatology-Department of Systems Medicine, University of Rome Tor Vergata, PTV – Policlinico Tor Vergata, V.le Oxford 81, Rome, 00133, Italy, Tel +39 0620902743, Fax +39 0620902742, Email [email protected]
Purpose: Secukinumab is a fully human monoclonal antibody that inhibits interleukin (IL)-17A approved for the treatment of moderate to severe plaque psoriasis in adults and children. We compared the efficacy and safety of secukinumab in patients aged < 65 years (adult patients) versus patients aged ≥ 65 years (elderly patients) in a post-hoc analysis of the SUPREME study.
Patients and Methods: Patients with moderate to severe plaque psoriasis received subcutaneous secukinumab 300 mg per week for the first 5 weeks, then 300 mg per month. We compared the following outcomes in patients aged ≥ 65 years vs < 65 years: baseline characteristics; PASI50/75/90/100 response rates (improvements ≥ 50%/75%/90%/100% in Psoriasis Area and Severity Index (PASI) from baseline); changes in Dermatology Life Quality Index (DLQI); Hospital Anxiety and Depression Scale (HAD-A, HAD-D) score changes; treatment-emergent adverse events (TEAEs).
Results: Secukinumab was slightly less effective in elderly patients than in adult patients (response rates at week 16: PASI90, 69.4% vs 80.9%, p = 0.4528; PASI100, 44.4% vs 56.7%, p = 0.8973). Elderly and adult patients showed a similar time course of changes in absolute PASI scores. Patients aged ≥ 65 years had a statistically significantly lower improvement in quality of life (mean DLQI reduction) than patients aged < 65 years at week 16 [− 5.4 (± 4.3) vs − 8.8 (± 6.9), p = 0.0065] and at week 24 [− 5.3 (± 4.4) vs − 9.2 (± 7.1), p = 0.0038]. Secukinumab treatment resulted in comparable mean reductions in anxiety and depression scores in both cohorts at 24 weeks [HAD-A, − 1.3 (± 3.3) vs − 2.1 (± 3.8), p = 0.9004; HAD-D, − 1.0 (± 3.3) vs − 1.5 (± 3.1), p = 0.4598]. The frequency of TEAEs in the two cohorts was similar (16.7% vs 14.6%, p = 0.7391).
Conclusion: Secukinumab is a valid option for the management of moderate to severe psoriasis in elderly patients.
Keywords: psoriasis, biologics, interleukin-17A, secukinumab, elderly
Introduction
Psoriasis is a common inflammatory, immune-mediated skin disease; its prevalence tends to increase with age.1–3 Due to the steadily increasing number of people aged ≥ 65 years worldwide, the population of geriatric patients with psoriasis is expanding.4–6 The management of psoriasis in the elderly can be difficult as the presence of comorbidities and the resulting use of concomitant medications, organ dysfunction, impaired immune system, and altered pharmacokinetics complicate the balancing of benefits and adverse effects of anti-psoriasis treatment.5,7,8 The use of topical medications is complex in this age group and the compliance to topical therapies is generally low. Also, patients aged ≥ 65 years are usually excluded from clinical studies and, therefore, evidence-based guidance for dermatologists is lacking.
The introduction of targeted systemic therapies with biologics has considerably improved the management of moderate to severe psoriasis.9 Secukinumab, a fully human monoclonal antibody that inhibits interleukin (IL)-17A is approved by the European Medicines Agency (EMA) for the treatment of moderate to severe plaque psoriasis in adults and children, psoriatic arthritis, axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis), and juvenile idiopathic arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). Evidence of its effectiveness in elderly patients with psoriasis is limited.5
The recent SUPREME study (NCT02394561) was performed to determine whether the presence of the allele HLA-Cw6 within the chromosomal psoriasis susceptibility gene 1 (PSORS1) influences the response to treatment with secukinumab.10,11 The study showed that secukinumab ensures high rates of skin clearance regardless of HLA-Cw6 status.10,11 Here we present the results of a post-hoc analysis of the SUPREME study comparing the efficacy and safety of secukinumab in patients aged < 65 years (adult patients) versus patients aged ≥ 65 years (elderly patients).
Materials and Methods
The design of the SUPREME study has been described in detail in a previous report.10 Briefly, SUPREME was a 24-week, phase IIIb, multicentre, prospective study conducted across 50 centers in Italy, with an extension period of up to 72 weeks, and involving patients aged ≥ 18 years with moderate to severe plaque psoriasis. Eligible patients were treated with subcutaneous secukinumab 300 mg per week for the first 5 weeks, followed by a maintenance period of 300 mg per month.
The post-hoc analysis of SUPREME presented here compared the following outcomes in patients aged ≥ 65 years vs patients aged < 65 years: baseline characteristics; PASI50/75/90/100 response rates (improvements ≥ 50%/75%/90%/100% in Psoriasis Area and Severity Index (PASI) from baseline); changes in Dermatology Life Quality Index (DLQI); Hospital Anxiety and Depression Scale (HAD-A, HAD-D) score changes; treatment-emergent adverse events (TEAEs). Results are reported as absolute numbers and percentages or mean ± standard deviation (SD) as appropriate. Significance tests for differences between patient groups included t-test, Wilcoxon test, chi-square test, or Fisher exact test as appropriate. A nominal p-value of < 0.05 was considered statistically significant. A logistic regression model was used to evaluate difference in PASI response (taking into account the following covariates: height, weight, waist, age at psoriasis diagnosis and presence of metabolic syndrome), while Kaplan-Meier survival curve and Log rank test was used for time to reach PASI responses. All statistical analyses were performed using SAS software 9.2 (SAS Institute, Cary, NC, US).
Results
Of the 433 patients treated in the SUPREME study, 36 (8.3%) were aged ≥ 65 years. Mean age was 69.2 (±4.2) years and 43.1 (±11.5) years in the elderly and adult cohorts, respectively. In both cohorts, males were predominant [26/36 (72.2%) and 284/397 (71.5%), respectively]. Elderly patients had a higher mean waist circumference [101.9 (±14.1) vs 96.1 (±15.1) cm; p = 0.0336], were older at diagnosis [45.5 (±14.6) vs 25.8 (±12.8) years old; p < 0.0001] and suffered more frequently of comorbidities (83.3% vs 60.2%; p = 0.0061), in particular metabolic syndrome (41.7% vs 14.4%; p < 0.0001). Significantly fewer older patients were current smokers (27.8% vs 48.6%, p = 0.0012). Mean PASI score at baseline was numerically lower for elderly patients [19.5 (±7.7) vs 21.3 (±9.7); p = 0.2587)] who showed, however, a significantly greater rate of prior therapies with anti-TNFα biologics (44.4% vs 28.2%; p = 0.0410). In both cohorts, biologics were discontinued mostly due to lack or loss of efficacy. Of note, most elderly patients (75%) interrupted biologic therapy for loss of efficacy.
Especially in terms of PASI90 and PASI100 responses, secukinumab was slightly less efficacious in elderly patients than in adult patients (response rates at week 16: PASI90, 69.4% vs 80.9%, p = 0.4528 (Figure 1A); PASI100, 44.4% vs 56.7%, p = 0.8973). The time to first PASI90 response was similarly short in both cohorts (median time to PASI90 response, 61 vs 58 days, respectively; log-rank, 0.1761). Elderly and adult patients showed a similar time course of changes in absolute PASI scores (Figure 1B).
 |
Figure 1 Efficacy of treatment with secukinumab in patients with moderate to severe psoriasis stratified by age < 65 years and ≥ 65 years. (A) PASI90 response rates during treatment. (B) Absolute PASI scores during treatment. |
Elderly patients had a statistically significantly lower improvement in quality of life (mean DLQI reduction) than adult patients at week 16 [−5.4 (±4.3) vs −8.8 (±6.9), p = 0.0065] and at week 24 [−5.3 (±4.4) vs −9.2 (±7.1), p = 0.0038]. At week 16, significantly fewer older patients achieved DLQI 0/1 than adult patients (51.5% vs 71.7%, p = 0.0157). Secukinumab treatment resulted in comparable mean reductions in anxiety and depression scores in both cohorts at 24 weeks [HAD-A, −1.3 (±3.3) vs −2.1 (±3.8), p = 0.9004; HAD-D, −1.0 (±3.3) vs −1.5 (±3.1), p = 0.4598].
The frequency of TEAEs in the two cohorts was similar (respectively, 16.7% vs 14.6%, p = 0.7391) (Table 1).
 |
Table 1 Summary of TEAEs |
Discussion
This post-hoc analysis of the SUPREME study provides a glimpse of the characteristics of elderly patients with moderate to severe plaque psoriasis and the outcomes of systemic treatment with secukinumab. Elderly patients accounted for less than 10% of the SUPREME population confirming the limited presence of patients aged ≥ 65 years in clinical studies. The baseline characteristics of this subgroup were in line with those reported in other studies evaluating older patients, including the higher frequency of comorbidities, lower frequency of current smoking, and later disease onset.4,8,12,13 Secukinumab was efficacious and well tolerated through week 24 regardless of age. PASI90 and PASI100 response rates tended to be lower in patients aged ≥ 65 years than in younger patients, but the differences between the two cohorts were not statistically significant. Improvements in quality of life during treatment were also less pronounced in elderly patients.
Few studies have addressed the efficacy and safety of secukinumab in psoriasis patients aged ≥ 65 years. A pooled analysis of three Phase III trials evaluated secukinumab after patient stratification by age and found equivalent efficacy of this anti-IL17 in patients aged ≥ 65 years and in younger patients.12 The rapidity and duration of response were also similar between older and younger patients, in agreement with our observations.12 A retrospective analysis investigating the effectiveness of anti-IL17 therapies for psoriasis in elderly patients confirmed the efficacy results reported in clinical trials.13 Notably, elderly and younger patients had a similar profile of adverse events, despite the higher frequency of comorbidities of the elderly subgroup.13 The safety findings of our analysis confirm this observation.
The fact that the improvement of the quality of life of the elderly patients treated with secukinumab in the SUPREME study was significantly inferior to that experienced by patients aged < 65 years may reflect the greater disease and treatment burden on elderly patients. At the same time, it highlights the need for tools able to describe more adequately outcomes relevant to the older population. As pointed out by a recent survey among psoriasis patients from different age groups, greater efforts should be devoted to the individualized management of elderly with psoriasis, because their needs differ substantially from those of younger patients with psoriasis.4,14 A personalized approach to elderly patients with psoriasis may reduce the disease burden and improve treatment outcomes.
Our analysis is limited by its post-hoc nature and the small number of elderly patients in the SUPREME study.
Conclusion
We believe that this analysis provides useful information on the use of secukinumab in patients aged ≥65 years and confirms that this anti-IL17 agent is a valid option for the management of moderate to severe psoriasis in elderly patients.
Data Sharing Statement
The statistically analyzed data is available in the text, and the detailed data will be available on request from the corresponding author.
Ethics Statement
All patients provided written informed consent before enrolment into the study. The study was approved by all competent Ethics Committees and regulatory authorities (Supplementary Table 1). The trial was conducted in accordance with the Declaration of Helsinki and Good Clinical Practice, and in compliance with all federal, local and regional requirements.
Acknowledgments
Study group: Paolo Amerio; Anna Balato; Luca Bianchi; Claudio Bonifati; Cinzia Buligan; Martina Burlando; Giacomo Caldarola; Piergiacomo Calzavara Pinton; Anna Campanati; Alessandra Capo; Maurizio Congedo; Andrea Conti; Francesco Cusano; Stefano Dastoli; Clara De Simone; Micol Del Giglio; Luisa Di Costanzo; Vito Di Lernia; Sergio Di Nuzzo; Daniele Dusi; Gabriella Fabbrocini; Rosaria Fidanza; Chiara Franchi; Francesca Gaiani; Marco Galluzzo; Alberto Ghilardi; Giampiero Girolomoni; Federica Giuliani; Dario Graceffa; Francesco Loconsole; Valentina Mastrandrea; Matteo Megna; Santo Raffaele Mercuri; Giuseppe Micali; Maria Letizia Musumeci; Luigi Naldi; Alessandra Narcisi; Ylenia Natalini; Annamaria Offidani; Diego Orsini; Gianluca Pagnanelli; Annalisa Patrizi; Monica Pau; Giovanni Pellacani; Ketty Peris; Severino Persechino; Stefano Piaserico; Lucia Pietroleonardo; Francesca Prignano; Marco Romanelli; Franco Rongioletti; Roberta Scuderi; Riccardo Sirna; Nevena Skroza; Giuseppe Stinco; Luca Stingeni; Marina Venturini; Leonardo Zichichi; Antonio Zini.
Funding
The SUPREME study was supported by Novartis Pharma AG.
Disclosure
M.T. has nothing to disclose; F.R. acted as speaker and consultant for Sanofi, AbbVie and Novartis, outside the submitted work; G.M. has nothing to disclose; K.H. reports personal fees from AbbVie, Almirall, Ganassini, LEO Pharma, Novartis, and Sanofi, outside the submitted work; M.P. has nothing to disclose; A.Ca. has nothing to disclose; A.P. has nothing to disclose; A.Ch. served as advisory board member and consultant and has received fees and speaker’s honoraria or has participated in clinical trials for AbbVie, Almirall, Incyte, LEO Pharma, Lilly, Janssen, Novartis, Pfizer, and Sanofi Genzyme; P.M. has nothing to disclose; F.B. has nothing to disclose; V.B. has nothing to disclose. P.D. has nothing to disclose; P.G. reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events for AbbVie, Almirall, Amgen, Janssen, LEO Pharma, Eli Lilly, Novartis, Pierre Fabre, Pfizer, Sandoz, Sanofi, UCB. C.Z. has nothing to disclose; C.P. has nothing to disclose; F.C. has nothing to disclose; MC.F. has served on advisory boards, received honoraria for lectures and research grants from Amgen, Almirall, AbbVie, BMS, Galderma, Kyowa Kirin, Leo Pharma, Pierre Fabre, UCB, Lilly, Pfizer, Janssen, MSD, Novartis, Sanofi-Regeneron, Sun Pharma.; S.T. acted as a speaker for AbbVie, Novartis and Janssen; P.B. has nothing to disclose; L.P. has nothing to disclose; G.G., M.B., L.C., and E.A. are employees of Novartis. AC received speaker’s/consultancy honoraria or grants for research from AbbVie, Almirall, Amgen, LEO Pharma, Novartis, Janssen, UCB, and Lilly. The authors report no other conflicts of interest in this work.
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