Back to Journals » Clinical Ophthalmology » Volume 8

Effects of treatment with bimatoprost 0.03% for 3 years in patients with normal-tension glaucoma

Authors Inoue K, Shiokawa M, Fujimoto T, Tomita G

Received 11 January 2014

Accepted for publication 8 May 2014

Published 19 June 2014 Volume 2014:8 Pages 1179—1183


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Kenji Inoue,1 Minako Shiokawa,1 Takayuki Fujimoto,1 Goji Tomita2

1Inouye Eye Hospital, Tokyo, Japan; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan

Purpose: To evaluate the effects of bimatoprost 0.03% single treatment for 3 years on intraocular pressure (IOP) and visual field performance.
Methods: We monitored the IOP of 62 patients with normal-tension glaucoma every
1–3 months. The Humphrey visual field test was performed every 6 months after treatment and the results obtained were compared to those before treatment. In addition, visual field performance was evaluated using trend and event analysis.
Results: The mean ± standard deviation (SD) of IOP after treatment with bimatoprost for 3 years (13.6±3.1 mmHg) was significantly lower than that before treatment (16.8±2.4 mmHg, P<0.0001). No change was observed in the mean deviation and pattern SD values of the Humphrey visual field before and 3 years after treatment. Worsening of visual field performance was observed in one patient (3.0%) by using trend analysis and in four patients (12.1%) by using event analysis. Treatment was discontinued in 17 patients (27.4%) because of adverse reactions.
Conclusion: Bimatoprost 0.03% single treatment was effective in reducing the IOP at least during the 3 years of treatment, but visual field performance worsened by 3.0%–12.1% in patients with normal-tension glaucoma.

Keywords: IOP, visual field, trend analysis, event analysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]