Effects of Lactoferrin on Subjective Skin Conditions in Winter: A Preliminary, Randomized, Double-Blinded, Placebo-Controlled Trial
Authors Oda H, Miyakawa M, Mizuki M, Misawa Y, Tsukahara T, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Received 22 August 2019
Accepted for publication 23 November 2019
Published 2 December 2019 Volume 2019:12 Pages 875—880
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 4
Editor who approved publication: Dr Jeffrey Weinberg
Hirotsugu Oda,1 Momoko Miyakawa,1 Masaru Mizuki,2 Yuka Misawa,3 Teruomi Tsukahara,2 Miyuki Tanaka,1 Koji Yamauchi,1 Fumiaki Abe,1 Tetsuo Nomiyama2
1Food Ingredients and Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd, Zama, Kanagawa 252-8583, Japan; 2Department of Preventive Medicine and Public Health, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan; 3Department of Rehabilitation, Nagano Children’s Hospital, Nagano 399-8288, Japan
Correspondence: Hirotsugu Oda
Food Ingredients and Technology Institute, R&D Division, Morinaga Milk Industry Co., Ltd., 5-1-83, Zama, Kanagawa 252-8583, Japan
Tel +81 46 252 3045
Fax +81 46 252 3017
Objective: To investigate the effects of lactoferrin (LF) on subjective skin conditions in winter.
Design: A preliminary, randomized, double-blinded, placebo-controlled trial.
Setting and subjects: Healthy adults in Japan.
Interventions: Intake of placebo, 200 mg, or 600 mg of LF for 12 weeks in winter.
Endpoints: Changes in the scores of subjective skin conditions.
Results: Three hundred and forty-six subjects were randomized. Nine subjects (placebo, n=0; 200 mg, n=5; 600 mg, n=4) withdrew consent, and 7 subjects (placebo, n=4; 200 mg, n=2; 600 mg, n=1) were lost to follow-up, resulting in 330 for a full analysis set.
Outcomes: Changes in the scores of moisture were greater in the 600 mg group than in the placebo group. Changes in the scores of moisture were greater in the 200 mg and 600 mg groups, and of texture were greater in the 600 mg group than in the placebo group in female subjects.
Conclusion: Intake of LF may improve moisture or texture of skin in winter.
Keywords: lactoferrin, winter, skin, moisture, texture
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