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Effects of carbon nanofiber on physiology of Drosophila

Authors Lee SH, Lee HY, Lee EJ, Khang D, Min KJ

Received 11 February 2015

Accepted for publication 16 April 2015

Published 21 May 2015 Volume 2015:10(1) Pages 3687—3697

DOI https://doi.org/10.2147/IJN.S82637

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster

Shin-Hae Lee,1,* Hye-Yeon Lee,1,* Eun-Ji Lee,1,* Dongwoo Khang,2 Kyung-Jin Min1

1Department of Biological Sciences, Inha University, Incheon, Republic of Korea; 2Department of Molecular Medicine, Graduate School of Medicine, Gachon University, Incheon, Republic of Korea

*These authors contributed equally to this work

Abstract: As nanomaterials are now widely utilized in a wide range of fields for both medical and industrial applications, concerns over their potential toxicity to human health and the environment have increased. To evaluate the toxicity of long-term exposure to carbon nanofibers (CNFs) in an in vivo system, we selected Drosophila melanogaster as a model organism. Oral administration of CNFs at a concentration of 1,000 µg/mL had adverse effects on fly physiology. Long-term administration of a high dose of CNFs (1,000 µg/mL) reduced larval viability based on the pupa:egg ratio, adult fly lifespan, reproductive activity, climbing activity, and survival rate in response to starvation stress. However, CNFs at a low concentration (100 µg/mL) did not show any significant deleterious effect on developmental rate or fecundity. Furthermore, long-term administration of a low dose of CNFs (100 µg/mL) increased lifespan and climbing ability, coincident with mild reactive oxygen species generation and stimulation of the antioxidant system. Taken together, our data suggest that a high dose of CNFs has obvious physiological toxicity, whereas low-dose chronic exposure to CNFs can actually have beneficial effects via stimulation of the antioxidant defense system.

Keywords: toxicity, Drosophila melanogaster, lifespan, reactive oxygen species

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