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Effects of BAK-free travoprost treatment for 3 years in patients with normal tension glaucoma

Authors Inoue K, Iwasa M, Wakakura M, Goji Tomita

Received 11 May 2012

Accepted for publication 5 July 2012

Published 15 August 2012 Volume 2012:6 Pages 1315—1319


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Kenji Inoue,1 Mayumi Iwasa,1 Masato Wakakura,1 Goji Tomita2

1Inouye Eye Hospital, 2Toho University Ohashi Medical Center, Tokyo, Japan

Background: The purpose of this study was to evaluate the effects of benzalkonium (BAK)-free travoprost monotherapy administered for 3 years on intraocular pressure and visual field performance.
Methods: The intraocular pressure of 76 patients with normal tension glaucoma was monitored every 1–3 months. A Humphrey visual field test was performed every 6 months after treatment and compared with the results before treatment. Visual field performance was also evaluated by trend and event analysis.
Results: Thirty cases discontinued within 3 years. Mean intraocular pressure after 3 years of travoprost treatment (14.1 ± 2.4 mmHg) was significantly lower than that before treatment (16.8 ± 2.6 mmHg, P ‹ 0.0001). There was no change in the mean deviation and pattern standard deviation as measured by Humphrey visual field test after 3 years of treatment compared with before treatment. Visual field performance was worse in one patient (2.8%) by trend analysis and five patients (13.9%) by event analysis. Treatment was discontinued in six cases (7.9%) due to the appearance of adverse reactions.
Conclusion: BAK-free travoprost monotherapy was effective in reducing intraocular pressure for at least 3 years; however, visual field performance worsened in 2.8%–13.9% of patients with normal tension glaucoma.

Keywords: BAK-free travoprost, intraocular pressure, visual field, trend analysis, event analysis

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