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Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model

Authors Awara A, Atiba A, Helal D, Elbedewy H

Received 31 December 2019

Accepted for publication 29 January 2020

Published 13 February 2020 Volume 2020:14 Pages 431—435

DOI https://doi.org/10.2147/OPTH.S244287

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1

1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, Egypt

Correspondence: Amr Awara
Ophthalmology Department, Tanta University, Tanta 31511, Egypt
Tel +2-01274005384
Fax +20403415008
Email amrawara@gmail.com

Background: Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.
Methods: An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.
Results: Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.
Conclusion: Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.

Keywords: eye allergy, cyclosporine A, eosinophilia, subconjunctival


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