Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes

Authors Subongkot T, Ngawhirunpat T

Received 15 April 2015

Accepted for publication 16 May 2015

Published 17 July 2015 Volume 2015:10(1) Pages 4581—4592

DOI https://doi.org/10.2147/IJN.S86624

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Carlos Rinaldi

Thirapit Subongkot,1 Tanasait Ngawhirunpat2

1
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Burapha University, Chonburi, Thailand; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand

Abstract: The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration.

Keywords: ultradeformable liposomes, terpenes, fluidity, electron spin resonance spectroscopy, confocal laser scanning microscopy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

A combined approach of hollow microneedles and nanocarriers for skin immunization with plasmid DNA encoding ovalbumin

Pamornpathomkul B, Wongkajornsilp A, Laiwattanapaisal W, Rojanarata T, Opanasopit P, Ngawhirunpat T

International Journal of Nanomedicine 2017, 12:885-898

Published Date: 27 January 2017

Mechanistic study of decreased skin penetration using a combination of sonophoresis with sodium fluorescein-loaded PEGylated liposomes with D-limonene

Rangsimawong W, Opanasopit P, Rojanarata T, Ngawhirunpat T

International Journal of Nanomedicine 2015, 10:7413-7423

Published Date: 15 December 2015

Readers of this article also read:

Effects of silver nanoparticles on neonatal testis development in mice

Zhang XF, Gurunathan S, Kim JH,

International Journal of Nanomedicine 2015, 10:6243-6256

Published Date: 5 October 2015

In vitro study of novel gadolinium-loaded liposomes guided by GBI-10 aptamer for promising tumor targeting and tumor diagnosis by magnetic resonance imaging

Gu MJ, Li KF, Zhang LX, Wang H, Liu LS, Zheng ZZ, Han NY, Yang ZJ, Fan TY

International Journal of Nanomedicine 2015, 10:5187-5204

Published Date: 17 August 2015

Niosomal carriers enhance oral bioavailability of carvedilol: effects of bile salt-enriched vesicles and carrier surface charge 

Arzani G, Haeri A, Daeihamed M, Bakhtiari-Kaboutaraki H, Dadashzadeh S

International Journal of Nanomedicine 2015, 10:4797-4813

Published Date: 29 July 2015

CaCO3/CaIP6 composite nanoparticles effectively deliver AKT1 small interfering RNA to inhibit human breast cancer growth

Zhou H, Wei J, Dai Q, Wang L, Luo J, Cheang T, Wang S

International Journal of Nanomedicine 2015, 10:4255-4266

Published Date: 1 July 2015

Targeted tumor imaging of anti-CD20-polymeric nanoparticles developed for the diagnosis of B-cell malignancies

Capolla S, Garrovo C, Zorzet S, Lorenzon A, Rampazzo E, Spretz R, Pozzato G, Núñez L, Tripodo C, Macor P, Biffi S

International Journal of Nanomedicine 2015, 10:4099-4109

Published Date: 22 June 2015

Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect

Pal A, Talukdar D, Roy A, Ray S, Mallick A, Mandal C, Ray M

International Journal of Nanomedicine 2015, 10:3499-3518

Published Date: 12 May 2015

Delivery of microRNA-146a with polyethylenimine nanoparticles inhibits renal fibrosis in vivo

Morishita Y, Imai T, Yoshizawa H, Watanabe M, Ishibashi K, Muto S, Nagata D

International Journal of Nanomedicine 2015, 10:3475-3488

Published Date: 11 May 2015

Pluronic® L64-mediated stable HIF-1α expression in muscle for therapeutic angiogenesis in mouse hindlimb ischemia

Song H, Liu S, Li C, Geng Y, Wang G, Gu Z

International Journal of Nanomedicine 2014, 9:3439-3452

Published Date: 21 July 2014