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Effect of ketamine combined with butorphanol on emergence agitation of postoperative patients with gastric cancer

Authors Lin L, Liu SC, Chen ZY, Lin SL

Received 23 December 2015

Accepted for publication 26 January 2016

Published 4 May 2016 Volume 2016:12 Pages 713—717

DOI https://doi.org/10.2147/TCRM.S103060

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Deyun Wang

Liang Lin, Shuncui Liu, Zhenyi Chen, Shaoli Lin

Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of China

Background: This study aimed to investigate the effect of ketamine combined with butorphanol on emergence agitation (EA) in postoperative gastric cancer patients.
Materials and methods: A total of 150 patients with gastric cancer were included and divided into group B (1 mg butorphanol before anesthesia induction, n=50), group K (1 mg/kg ketamine, n=50), and group C (1 mg butorphanol combined with 1 mg/kg ketamine, n=50). Mean arterial pressure (MAP) and heart rate (HR) at the end of operation, just before extubation (T0) and at 0 minute (T1), 5 minutes (T2), and 30 minutes (T3) after extubation were compared. Statistical analysis of recovery time, extubation time, time in postanesthesia care unit, and EA incidence and adverse reactions were performed.
Results: There were no differences among groups with respect to MAP and HR at T0 and T1 (P>0.05). Compared with patients in group C, significant reduction of MAP and HR were observed in groups K and B at T2 and T3 (P<0.05), while no differences were found between group K and group B (P>0.05). Recovery time, extubation time, time in postanesthesia care unit, and incidence of EA in group C were significantly less than those in groups K and B (P<0.05), but no differences were observed between group K and group B (P>0.05). Total incidence of adverse reactions were significantly increased in group K compared to those in groups C and B (P<0.05).
Conclusion:
Injection of ketamine combined with butorphanol before anesthesia induction was more effective than injection of ketamine or butorphanol separately in the prevention of EA.

Keywords:
emergence agitation, ketamine, butorphanol, gastric cancer

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