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Effect of anterior chamber depth on predictive accuracy of seven intraocular lens formulas in eyes with axial length less than 22 mm

Authors Shrivastava AK, Behera P, Kacher R, Kumar B

Received 31 May 2019

Accepted for publication 16 July 2019

Published 20 August 2019 Volume 2019:13 Pages 1579—1586

DOI https://doi.org/10.2147/OPTH.S217932

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Ankur K Shrivastava, Pranayee Behera, Rajaram Kacher, Binod Kumar

Department of Ophthalmology, All India Institute of Medical Sciences, Raipur, India

Correspondence: Ankur K Shrivastava
Department of Ophthalmology, All India Institute of Medical Sciences, Flat No 603, Type 5A, AIIMS residential complex, Kabir Nagar, Raipur, Chhattisgarh 492099, India
Tel +91 971 310 0777
Email shrivastavadrankur@gmail.com

Purpose: This study aimed to evaluate whether different anterior chamber depth (ACD) affects the predictive accuracy of intraocular lens formulas in eyes with axial length (AL) less than 22 mm.
Methods: Eighty-five eyes of 85 patients with AL less than 22 mm were included in this retrospective study, which were divided into three groups: Group 1, ACD less than 2.4 mm; Group 2, ACD between 2.4 and 2.9 mm; and Group 3, ACD greater than 2.9 mm. Optical biometry with partial coherence interferometry was performed in all cases. The median absolute error (MedAE) was compared by Friedman’s test, using the optimized lens constant, among seven formulas (Barrett Universal II, Haigis, Hill-RBF, Hoffer Q, Holladay 1, Holladay 2, and SRK/T) in each group.
Results: Friedman’s test showed no significant difference in MedAE among all formulas in Groups 1 and 3. However, as the Haigis formula had the highest MedAE and lowest percentage of eyes within ±0.25 Diopter, it is least preferred in Group 1. On the contrary, in Group 3 it fared the best, having the least MedAE and highest percentage of eyes within ±0.25 Diopter. In Group 2, Friedman’s test gave significant difference, and post-hoc analysis showed statistical superiority of Haigis over the Holladay 1 (p=0.02), Holladay 2 (p=0.01), Hill-RBF (p=0.04), and SRK/T (p=0.02) formulas. However, there was no statistical difference between the Barrett Universal II, Haigis, and Hoffer Q formulas.
Conclusion: Considering the ACD in eyes with AL less than 22 mm, Haigis is the preferred formula while SRK/T proved to be the worst formula in Groups 2 and 3.

Keywords: short axial length, optical biometry, anterior chamber depth, intraocular lens formulas, optimized lens constant

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