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Early interventions to prevent retinal vasculopathy in diabetes: a review

Authors Harrison W, Yevseyenkov V

Received 25 April 2015

Accepted for publication 2 July 2015

Published 31 August 2015 Volume 2015:7 Pages 71—80

DOI https://doi.org/10.2147/OPTO.S68270

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Mr Simon Berry

Wendy W Harrison, Vladimir Yevseyenkov

Arizona College of Optometry, Midwestern University, Glendale, AZ, USA

Abstract: Diabetic eye disease is a public health concern in all areas of the world as a leading cause of blindness in the working aged to elderly populations. Diabetes damages the lining of the microvasculature throughout the body through prolonged exposure to hyperglycemic conditions. The ocular changes are progressive with very little recourse for improvement once damage begins. Current treatments for the eye focus mainly on the late stages of the disease when neovascularization or edema threatens sight. Early interventions for diabetic vasculopathy involve metabolic therapy to improve blood glucose and blood pressure control. Technology improvements have a large part to play in advancing diagnosis of diabetic eye disease. These new technologies offer both structural and functional means for assessment of retinal health. This review focuses on current treatments for diabetic eye disease at all stages with an emphasis on new and early interventions. It also details established and emerging technologies used for earlier detection of diabetic eye disease, which is vital to the development and approval of much needed treatments targeted at earlier stages of diabetic retinopathy. Possible future treatments should be aimed to prevent retinal vasculopathy from progressing. This review will explore current research on this topic and what is needed moving forward.

Keywords:
diabetes, diabetic retinopathy, vascular disease

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