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Drugs under preclinical and clinical study for treatment of acute and chronic lymphoblastic leukemia

Authors Jacob JA, Salmani JMM, Chen B

Received 29 March 2016

Accepted for publication 3 May 2016

Published 20 June 2016 Volume 2016:10 Pages 1115—1119


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Naifeng Liu

Joe Antony Jacob, Jumah Masoud Mohammad Salmani, Baoan Chen

Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People’s Republic of China

Abstract: Targeted therapy has modernized the treatment of both chronic and acute lymphoblastic leukemia. The introduction of monoclonal antibodies and combinational drugs has increased the survival rate of patients. Preclinical studies with various agents have resulted in positive outputs with Phase III trial drugs and monoclonal antibodies entering clinical trials. Most of the monoclonal antibodies target the CD20 and CD22 receptors. This has led to the approval of a few of these drugs by the US Food and Drug Administration. This review focuses on the drugs under preclinical and clinical study in the ongoing efforts for treatment of acute and chronic lymphoblastic leukemia.

Keywords: targeted therapy, monoclonal antibodies, preclinical studies, receptors, lymphoblastic leukemia

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