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Drug-induced impairment of renal function

Authors Pazhayattil GS, Shirali A

Received 17 February 2014

Accepted for publication 23 April 2014

Published 12 December 2014 Volume 2014:7 Pages 457—468

DOI https://doi.org/10.2147/IJNRD.S39747

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


George Sunny Pazhayattil, Anushree C Shirali

Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA


Abstract: Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient care. However, all agents also carry adverse drug effect profiles. While most of these are clinically insignificant, some drugs may cause unacceptable toxicity that impacts negatively on patient morbidity and mortality. Recognizing adverse effects is important for administering appropriate drug doses, instituting preventive strategies, and withdrawing the offending agent due to toxicity. In the present article, we will review those drugs that are associated with impaired renal function. By focusing on pharmaceutical agents that are currently in clinical practice, we will provide an overview of nephrotoxic drugs that a treating physician is most likely to encounter. In doing so, we will summarize risk factors for nephrotoxicity, describe clinical manifestations, and address preventive and treatment strategies.

Keywords: acute kidney injury, chronic kidney disease, drug nephrotoxicity, chemotherapy, NSAIDs

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