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Doxycycline Combined with NB-UVB Phototherapy for Acquired Reactive Perforating Collagenosis

Authors Gao L, Gu L, Chen Z, Cao S

Received 10 July 2020

Accepted for publication 21 August 2020

Published 24 September 2020 Volume 2020:16 Pages 917—921

DOI https://doi.org/10.2147/TCRM.S271058

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Deyun Wang


Limu Gao, Lixiong Gu, Zhen Chen, Shuanglin Cao

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, People’s Republic of China

Correspondence: Shuanglin Cao
Department of Dermatology, Affiliated Hospital of Nantong University, 20th Xisi Road, Nantong, People’s Republic of China
Email slcao@medmail.com.cn

Background: Acquired reactive perforating collagenosis is a rare skin disease characterized by the discharge of collagen fibers through the epidermis. There is no standard treatment for this disease currently. Here, we report a case of ARPC that has been successfully treated and cured.
Case Description: A 32-year-old man developed severe itching papules on his torso and limbs for 3 months. Skin lesions were keratotic papules scattered on the limbs and trunk, with a diameter of 3 to 12 mm. Some lesions had umbilical recesses and the shape of a crater with positive isomorphic reactions. The patient scratched his severe itching lesions which merged into large ones. This patient had histories of hypertension and dilated cardiomyopathy with mild congestive heart failure. The clinical presentation and histopathology of skin lesions met Faver’s diagnostic criteria for ARPC.
Treatment: Oral Doxycycline 100mg/d, NB-UVB phototherapy 3 times a week with initial dose 400mJ/cm2, gradually increased to 1200mJ/cm2(total cumulative dose 16700J/cm2).
Outcomes: After a week of treatment, the patient’s itching symptoms were significantly reduced and stopped presenting any new skin lesions. Most of the lesions healed in 6 weeks of treatment.
Lessons: Doxycycline combined with NB-UVB may be an effective treatment for ARPC.

Keywords: acquired reactive perforating collagenosis, doxycycline, NB-UVB, hypertension

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