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Doege–Potter Syndrome, cause of nonislet cell tumor hypoglycemia: the first case report from Nepal

Authors Pant V, Baral S, Sayami G, Sayami P

Received 20 May 2017

Accepted for publication 27 July 2017

Published 16 August 2017 Volume 2017:10 Pages 275—278

DOI https://doi.org/10.2147/IMCRJ.S142260

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas


Vivek Pant,1 Suman Baral,2 Gita Sayami,3 Prakash Sayami4

1Department of Biochemistry, 2Endocrinology Unit, Department of Medicine, 3Department of Pathology, 4Manmohan Cardiothoracic vascular and transplant Center, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal

Abstract: Doege–Potter syndrome (DPS), a paraneoplastic syndrome, presents as a hypoinsulinemic hypoglycemia from the ectopic secretion of insulin-like growth factor II from a solitary fibrous tumor which may be intrapleural or extrapleural in origin. We report a case of severe hypoglycemia in a 70-year old female initially admitted for resection of left sided solitary fibrous tumor of pleura. Investigation revealed true hypoglycemia, and DPS was diagnosed. The tumor was completely resected, after which no further hypoglycemic episodes were seen in 2 years follow-up. This is the first case of solitary fibrous tumor of pleura with DPS reported from Nepal.

Keywords: insulin-like growth factor II, IGF-II, solitary fibrous tumor, hypoglycemia

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