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Do eyes with and without optic neuritis in multiple sclerosis age equally?

Authors Lizrova Preiningerova J, Grishko A, Sobisek L, Andelova M, Benova B, Kucerova K, Havrdova EK

Received 4 April 2018

Accepted for publication 29 May 2018

Published 5 September 2018 Volume 2018:14 Pages 2281—2285

DOI https://doi.org/10.2147/NDT.S169638

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Jana Lizrova Preiningerova,1 Anna Grishko,2 Lukas Sobisek,2 Michaela Andelova,1 Barbora Benova,1 Karolina Kucerova,1 Eva Kubala Havrdova1

1Center of Clinical Neuroscience, Department of Neurology, General University Hospital, 1st Faculty of Medicine, Charles University, Prague Czech Republic; 2Department of Statistics and Probability, University of Economics, Prague, Czech Republic

Purpose: Anterior visual pathway reflects axonal loss caused by both optic neuritis (ON) and neurodegeneration in multiple sclerosis (MS). Although the axonal injury post-ON is thought to be complete by 6 months of onset, most studies using optical coherence tomography (OCT) to evaluate retinal changes as a marker of neurodegeneration exclude eyes with a history of ON or consider them separately. The objective of this study was to assess whether the eyes post-ON (>6 months) show in later years different rate of chronic retinal changes than the fellow eyes not affected by ON.
Patients and methods: Fifty-six patients with MS with a history of ON in one eye (ON eyes) and no ON in the fellow (FL) eye, who were followed by OCT for >2 years, were selected from a cohort of patients with MS. Paired eye analysis was performed.
Results: Mean interval post-ON at baseline was 5.65 (SD 5.05) years. Mean length of follow-up by OCT was 4.57 years. There was no statistical difference in absolute or relative thinning of retinal nerve fiber layer in peripapillary area between the ON and FL eyes.
Conclusion: This study has shown that we do not need to exclude eyes with a history of ON from longitudinal studies of neurodegeneration in MS, provided that we use data outside of the frame of acute changes post-ON. Long-term changes of peripapillary retinal nerve fiber layer in ON and FL eyes are equal.

Keywords: optical coherence tomography, neurodegeneration, multiple sclerosis, retina

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