Back to Journals » ClinicoEconomics and Outcomes Research » Volume 7

Disability-adjusted life years lost due to diabetes in France, Italy, Germany, Spain, and the United Kingdom: a burden of illness study

Authors Darbà J, Kaskens L, Detournay B, Kern W, Nicolucci A, Orozco-Beltrán D, Ramirez de Arellano A

Received 25 November 2014

Accepted for publication 12 January 2015

Published 23 March 2015 Volume 2015:7 Pages 163—171


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Giorgio Colombo

Josep Darbà,1 Lisette Kaskens,2 Bruno Detournay,3 Werner Kern,4 Antonio Nicolucci,5 Domingo Orozco-Beltrán,6 Antonio Ramírez de Arellano7

1Department of Economics, University of Barcelona, Barcelona, Spain; 2Department of Health Economics, BCN Health Economics and Outcomes Research SL, Barcelona, Spain; 3Department of Health Economics, CEMKA-EVAL, Bourg-la-Reine, France; 4Department of Endocrinology, Endokrinologikum, Center for Hormone and Metabolism, Ulm, Germany; 5Department of Endocrinology, Mario Negri Sud Foundation, Santa Maria Imbaro, Italy; 6Department of Family Medicine, University Miguel Hernández, Alicante, Spain; 7Department of Health Economics, EU-HEOR Novo Nordisk, Madrid, Spain

Aims: To compare the burden of disease (BoD) attributable to diabetes expressed in disability-adjusted life years (DALYs) for five European countries in 2010.
Methods: DALYs lost to diabetes as the sum of years of life lost and years lived with disability were estimated by sex and age using country-specific epidemiological data and global disability weights. Data from various secondary sources were combined to estimate health loss due to diabetes for France, Germany, Italy, Spain, and the UK. National statistical databases were used and if necessary, community studies were used to derive the prevalence of diabetes by sex and age group, which were weighted proportionately for a national population burden of disease estimate. All identified data were adapted to the Global Burden of Disease methodology (2010) to calculate the burden attributable to diabetes. No age weighting and discounting was applied. Sensitivity to different sources of variation was examined. Germany and Italy lost the largest number of DALYs due to diabetes, with 5.9 and 5.8 per 1,000 inhabitants, respectively, followed by Spain (4.4), France (3.7), and the UK (2.9). The highest burden was caused by mortality due to diabetes, with the exception of the UK, for which the burden due to disability of diabetes was higher. Mean DALYs lost were higher for women in Germany, Italy, and Spain and shown to increase with age for all countries. Sensitivity analysis in variation in disability weights and uncertainty in epidemiological data were shown to have effects on DALYs lost.
Conclusion: In spite of data limitations, the estimates reported here show that DALY loss due to diabetes imposes a substantial burden on countries. Cross-national variation in disease epidemiology was the largest source of variation in the burden of diabetes between countries.

Keywords: prevalence, mortality, life expectancy, DALY

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Identification of factors involved in medication compliance: incorrect inhaler technique of asthma treatment leads to poor compliance

Darbà J, Ramírez G, Sicras A, García-Bujalance L, Torvinen S, Sánchez-de la Rosa R

Patient Preference and Adherence 2016, 10:135-145

Published Date: 9 February 2016

The importance of inhaler devices: the choice of inhaler device may lead to suboptimal adherence in COPD patients

Darbà J, Ramírez G, Sicras A, Francoli P, Torvinen S, Sánchez-de la Rosa R

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2335-2345

Published Date: 29 October 2015

Cost-utility of denosumab for the treatment of postmenopausal osteoporosis in Spain

Darbà J, Kaskens L, Sorio Vilela F, Lothgren M

ClinicoEconomics and Outcomes Research 2015, 7:105-117

Published Date: 9 February 2015

Budget impact analysis of the fentanyl buccal tablet for treatment of breakthrough cancer pain

Darbà J, Kaskens L, Sánchez-de la Rosa R

ClinicoEconomics and Outcomes Research 2014, 6:1-9

Published Date: 16 December 2013

Cost-effectiveness of bazedoxifene versus raloxifene in the treatment of postmenopausal women in Spain

Darbà J, Pérez-Álvarez N, Kaskens L, Holgado-Pérez S, Racketa J, Rejas J

ClinicoEconomics and Outcomes Research 2013, 5:327-336

Published Date: 5 July 2013

Readers of this article also read:

Hematuria following Botox treatment for upper limb spasticity: a case report

Lo TC, Yeung ST, Lee S, Chang EY

Journal of Pain Research 2015, 8:619-622

Published Date: 14 September 2015

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010