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Differential pharmacology and clinical utility of empagliflozin in type 2 diabetes

Authors Munir K, Davis S

Received 20 January 2016

Accepted for publication 9 March 2016

Published 20 April 2016 Volume 2016:8 Pages 19—34

DOI https://doi.org/10.2147/CPAA.S77754

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Professor Sushil Sharma

Peer reviewer comments 2

Editor who approved publication: Professor Arthur Frankel


Kashif M Munir,1 Stephen N Davis2

1Division of Endocrinology, Diabetes, and Nutrition, Center for Diabetes and Endocrinology, 2Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

Abstract: With rates of obesity and diabetes rising across the world, effective therapies to treat hyperglycemia and its associated comorbidities continue to be in demand. Empagliflozin is a highly selective sodium glucose transporter-2 inhibitor that improves serum glucose levels by inducing glucosuria. Taken orally, it is rapidly absorbed with linear pharmacokinetics consistent in Asian and Caucasian populations. Empagliflozin treatment demonstrates consistent reductions in hemoglobin A1c, fasting plasma glucose, body weight, and blood pressure in individuals with type 2 diabetes. Improvements in glycemic control and metabolic end points are evident with empagliflozin monotherapy, as add-on to oral hypoglycemics or add-on to insulin. The nonglycemic effects of empagliflozin with consistent improvements in blood pressure, body weight, and waist circumference provide additional rationale for use in patients with type 2 diabetes. Moreover, treatment with empagliflozin has recently shown significant reductions in both microvascular and macrovascular complications of diabetes.

Keywords: empagliflozin, type 2 diabetes, pharmacology, blood pressure, body weight, hemoglobin A1c, glucose

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