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Different durations of cognitive stimulation therapy for Alzheimer’s disease: a systematic review and meta-analysis

Authors Chen J, Duan Y, Li H, Lu L, Liu J, Tang C

Received 26 March 2019

Accepted for publication 15 June 2019

Published 12 July 2019 Volume 2019:14 Pages 1243—1254

DOI https://doi.org/10.2147/CIA.S210062

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Zhi-Ying Wu


Juexuan Chen,*,1 Yuting Duan,*,1,2 Huanjie Li,3 Liming Lu,1 Jihong Liu,3 Chunzhi Tang1

1Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, People’s Republic of China; 3Foshan Hospital of Traditional Chinese Medicine, Affiliated to Guangzhou University of Chinese Medicine, Foshan, People’s Republic of China

*These authors contributed equally to this work

Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer’s disease (AD).
Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.
Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.
Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

Keywords: cognitive stimulation therapy, Alzheimer’s disease, cognitive symptom, meta-analysis

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