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Diagnostic and Management Strategies of Aspergillus Endophthalmitis: Current Insights

Authors Spadea L, Giannico MI

Received 22 September 2019

Accepted for publication 16 December 2019

Published 24 December 2019 Volume 2019:13 Pages 2573—2582


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Leopoldo Spadea, Maria Ilaria Giannico

University “La Sapienza”, Department of Sense Organs, Eye Clinic, Rome, Italy

Correspondence: Leopoldo Spadea
Head Eye Clinic, Policlinico Umberto 1, “Sapienza” University of Rome, Via Benozzo Gozzoli 34, Rome 00142, Italy
Tel +39 06 519 3220
Fax +39 06 8865 7818

Abstract: Fungal endophthalmitis is subsequent to endogenous or exogenous infection and represents an important complication of ocular surgery which may lead to significant visual loss and blindness. The prognosis is poor because of delayed diagnosis and limited availability of effective antifungal drugs with good ocular penetration. Furthermore, the critical issue in diagnosing fungal infection of the eye is microbiological identification of the etiologic agent in clinical samples. Aspergillus is among the most frequent isolated organisms in fungal endophthalmitis. Early diagnosis is essential to prevent severe complications and blindness. Treatments include local, systemic and surgical therapeutic strategies. The purpose of the present review is the analysis of the current procedures adopted to promptly diagnose and treat Aspergillus endophthalmitis.

Keywords: Aspergillus, endophthalmitis, fungal infection, cataract surgery, ocular mycoses

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