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Dezocine for anesthesia and stress reduction in induced abortion

Authors Zheng M, Guo Y, Shan S, Yang S

Received 28 October 2014

Accepted for publication 23 December 2014

Published 3 March 2015 Volume 2015:9 Pages 369—372

DOI https://doi.org/10.2147/PPA.S76507

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen

Mengliang Zheng, Yanru Guo, Shiqiang Shan, Sen Yang

Department of Anesthesiology, Cangzhou Central Hospital, Hebei, People’s Republic of China

Background: The purpose of this study was to evaluate the efficacy of dezocine with regard to analgesic and stress reduction outcomes in women undergoing induced abortion.
Methods: A total of 126 women in early pregnancy (up to 14 weeks’ gestation) who underwent induced abortion at Cangzhou Central Hospital from May 2012 to May 2013 were randomly assigned to a control (propofol) group (n=63) or an intervention (propofol + dezocine) group (n=63). Wake-up time, orientation force recovery time, incidence of adverse reactions, postoperative visual analog scale (VAS) score, analgesic effect, and respiratory and circulatory monitoring before the operation, 5 minutes into the operation, and 5 minutes after the operation were compared between the two groups.
Results: The surgical procedure and anesthesia were performed successfully in all patients. Systolic and diastolic blood pressure and oxyhemoglobin saturation in the intervention group were significantly higher than in the control group; however, heart rate was significantly lower in the intervention group than in the control group 5 minutes into the operation (all P<0.05). There were no statistically significant differences in these parameters before surgery and after recovery. The postoperative VAS score (2.82±0.72), Ramsay score (2.65±0.65), and anesthetic effect in the intervention group were better than in the control group (3.90±0.84 and 2.21±0.49, respectively), and all differences were statistically significant (P<0.05). The wake-up time (3.41±0.79 minutes) and orientation force recovery time (4.28±0.92 minutes) were all significantly shorter (P<0.05) in the intervention group than in the control group, as was the incidence of adverse reactions (7.94% versus 26.98%, respectively).
Conclusion: Adverse reactions of propofol combined with dezocine in painless induced abortion are less while the analgesic effect is better.

Keywords: dezocine, painless induced abortion, stress, analgesic effect

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