Development and Study of Biocompatible Polyurethane-Based Polymer-Metallic Nanocomposites
Received 7 January 2020
Accepted for publication 19 February 2020
Published 31 March 2020 Volume 2020:13 Pages 11—22
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Professor Israel (Rudi) Rubinstein
István Csarnovics,1 Julia Burunkova,2 Danara Sviazhina,2 Evgeniy Oskolkov,2 George Alkhalil,2 Elena Orishak,3 Ludmila Nilova,3 István Szabó,1 Péter Rutka,1 Krisztián Bene,4 Attila Bácsi,4 Sándor Kökényesi1
1Institute of Physics, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary; 2International Scientific and Research Institute of Bioengineering, School of Photonics, ITMO University, St., Petersburg, Russian Federation; 3Department of Medical Microbiology, Faculty of Preventive Medicine, North-Western State Medical University Named After I.I. Mechnikov, St., Petersburg, Russian Federation; 4Department of Immunology, Faculty of Health, University of Debrecen, Debrecen, Hungary
Correspondence: István Csarnovics
University of Debrecen, Faculty of Science and Technology, Institute of Physics, Bem sq 18/a, Debrecen 4026, Hungary
Introduction: In this work we selected components, developed technology and studied a number of parameters of polymer nanocomposite materials, remembering that the material would have high optical and good mechanical characteristics, good sorption ability in order to ensure high value of the optical signal for a short time while maintaining the initial geometric shape. In addition, if this nanocomposite is used for medicine and biology (biocompatible or biocidal materials or the creation of a sensor based on it), the material must be non-toxic and/or biocompatible. We study the creation of polymer nanocomposites which may be applied as biocompatible materials with new functional parameters.
Material and Methods: A number of polymer nanocomposites based on various urethane-acrylate monomers and nanoparticles of gold, silicon oxides, zinc and/or titanium oxides are obtained, their mechanical (microhardness) properties and wettability (contact angle) are studied. The set of required, biology-related properties of these materials, such as toxicity and sorption of microorganisms are also investigated in order to prove their possible applicability.
Results and Discussion: The composition of the samples influences their microhardness and the value of contact angle, which means that varying with the monomer and the metallic, oxide nanoparticles composition, we could change these parameters. Besides it, the set of required, biology-related properties of these materials, such as toxicity and sorption of microorganisms were also investigated in order to prove their possible applicability. It was shown that the materials are non-toxic, the adhesion of microorganisms on their surface also could be varied by changing their composition.
Conclusion: The presented polymer nanocomposites with different compositions of monomer and the presence of nanoparticles in them are prospective material for a possible bio-application as it is biocompatible, not toxic. The sorption of microorganism could be varied depending on the type of bacterias, the monomer composition, and nanoparticles.
Keywords: polymer nanocomposites, metallic nanoparticles, oxide nanoparticles, biocompatible materials, microhardness
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]